Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | HTT | P42858 | 4/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.67 |
| ▸ | POLB | P06746 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | TSHR | P16473 | 6/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1094118 | 0.85 | MEN1 (0.73) | KMT2AMEN1HTTSMN1; SMN2POLB | |
| SCHEMBL31661903 | 0.85 | MEN1 (0.73) | KMT2AMEN1HTTSMN1; SMN2POLB | |
| SCHEMBL9568492 | 0.84 | KMT2A (0.72) | KMT2AMEN1HTTSMN1; SMN2POLB | |
| SCHEMBL10031630 | 0.84 | KMT2A (0.72) | KMT2AMEN1HTTSMN1; SMN2POLB | |
| SCHEMBL28644956 | 0.84 | KMT2A (1.00) | KMT2AMEN1HTTSMN1; SMN2POLB | |
| SCHEMBL8228775 | 0.84 | POLB (0.91) | KMT2AMEN1HTTSMN1; SMN2POLB | |
| SCHEMBL2801932 | 0.81 | KMT2A (0.68) | KMT2AMEN1HTTSMN1; SMN2POLB | |
| SCHEMBL2734370 | 0.80 | CA2 (0.68) | KMT2AMEN1HTTSMN1; SMN2POLB | |
| SCHEMBL9207324 | 0.80 | ALDH1A1 (0.69) | KMT2AMEN1HTTSMN1; SMN2POLB | |
| SCHEMBL1403148 | 0.79 | KMT2A (0.74) | KMT2AMEN1HTTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0532239-B1 | Benzenesulphonamide derivatives as 5-lipoxygenase inhibitors | ZENECA LTD (GB) | 1995-12-13 | — | — | EP | disclosed |
| US-5403857-A | Benzenesulphonamide derivatives having 5-lipoxygenase inhibitory activity | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-04-04 | — | — | US | disclosed |
| US-5314891-A | Lipoxygenase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-05-24 | — | — | US | disclosed |
| EP-0532239-A1 | Benzenesulphonamide derivatives as 5-lipoxygenase inhibitors | ZENECA LIMITED (GB) | 1993-03-17 | — | — | EP | disclosed |