Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 8/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18781369 | 0.77 | OPRL1 (0.61) | OPRL1OPRM1OPRK1TRPA1 | |
| SCHEMBL18781371 | 0.77 | OPRL1 (0.61) | OPRL1OPRM1OPRK1TRPA1 | |
| SCHEMBL31662753 | 0.75 | CYP1B1 (0.45) | OPRL1OPRM1OPRK1TRPA1CYP1B1 | |
| SCHEMBL4995780 | 0.72 | OPRL1 (0.41) | OPRL1OPRM1OPRK1TRPA1CYP1B1 | |
| SCHEMBL8025052 | 0.72 | OPRL1 (0.41) | OPRL1OPRM1OPRK1TRPA1CYP1B1 | |
| SCHEMBL13606955 | 0.70 | CHRM1 (0.41) | — | |
| SCHEMBL3484479 | 0.68 | HTR6 (0.36) | — | |
| SCHEMBL5441241 | 0.67 | BRPF1 (0.40) | OPRL1OPRM1OPRK1BRD4 | |
| SCHEMBL6302365 | 0.67 | OPRL1 (0.47) | OPRL1OPRM1OPRK1TRPA1CYP1B1 | |
| SCHEMBL28100125 | 0.66 | PDE1C (0.45) | OPRL1OPRM1OPRK1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0660833-A1 | 3,3'-DISUBSTITUTED-1,3-DIHYDRO-2H-PYRROLO 2,3-b]HETEROCYCLIC-2-ONE USEFUL IN THE TREATMENT OF COGNITIVE DISORDERS OF MAN | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-07-05 | — | — | EP | disclosed |
| WO-1994006793-A1 | 3,3'-DISUBSTITUTED-1,3-DIHYDRO-2H-PYRROLO[2,3-b]HETEROCYCLIC-2-ONE USEFUL IN THE TREATMENT OF COGNITIVE DISORDERS OF MAN | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1994-03-31 | — | — | WO | disclosed |
| US-5278162-A | Learning enhancement | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1994-01-11 | — | — | US | disclosed |