Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | BLM | P54132 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 4/20 | 0.32 |
| ▸ | NOS2 | P35228 | 4/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3129155 | 0.77 | MEN1 (0.37) | ALDH1A1HPGDKDM4EKMT2AMEN1 | |
| SCHEMBL1868060 | 0.73 | ALDH1A1 (0.36) | ALDH1A1HPGDKDM4EKMT2AMEN1 | |
| SCHEMBL3081411 | 0.72 | ALDH1A1 (0.38) | ALDH1A1HPGDKDM4EKMT2AMEN1 | |
| SCHEMBL7994953 | 0.71 | ALDH1A1 (0.46) | ALDH1A1HPGDKDM4EKMT2AMEN1 | |
| SCHEMBL10435536 | 0.70 | KDM4E (0.35) | ALDH1A1HPGDKDM4EKMT2AMEN1 | |
| SCHEMBL3619022 | 0.70 | ALDH1A1 (0.36) | ALDH1A1HPGDKDM4EKMT2AMEN1 | |
| SCHEMBL4103011 | 0.69 | ALDH1A1 (0.37) | ALDH1A1HPGDKDM4EKMT2AMEN1 | |
| SCHEMBL11708484 | 0.69 | HPGD (0.37) | ALDH1A1HPGDKDM4EKMT2AMEN1 | |
| SCHEMBL8735560 | 0.69 | ALDH1A1 (0.36) | ALDH1A1HPGDKDM4EKMT2AMEN1 | |
| SCHEMBL27272787 | 0.69 | ALDH1A1 (0.37) | ALDH1A1HPGDKDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665747-A4 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE. | MERCK & CO INC (US) | 1995-11-15 | — | — | EP | disclosed |
| EP-0665747-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO. INC. (US) | 1995-08-09 | — | — | EP | disclosed |
| US-5317017-A | N-biphenyl-3-amido substituted benzolactams stimulate growth hormone release | MERCK & CO., INC. (US) | 1994-05-31 | — | — | US | disclosed |
| WO-1994007483-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1994-04-14 | — | — | WO | disclosed |