SCHEMBL9211380

SCHEMBL9211380

O=C1N(c2ccccc2)c2ncccc2C1(Cc1ccncc1)Cc1ccncc1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.70
CYP1A2 P05177 2/20 0.70
CYP3A4 P08684 2/20 0.70
CYP2C9 P11712 2/20 0.70
CYP2D6 P10635 1/20 0.70
CYP2C19 P33261 1/20 0.70
THPO P40225 1/20 0.70
MAPK1 P28482 2/20 0.67
ELANE P08246 6/20 0.47
KCNQ2 O43526 1/20 0.47
ALOX15 P16050 1/20 0.47
TSHR P16473 1/20 0.47
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
HSD17B10 Q99714 1/20 0.43
EGLN1 Q9GZT9 2/20 0.41
ATM Q13315 1/20 0.39
MARK3 P27448 1/20 0.38
HTT P42858 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL9210703 0.99 MAPK1 (0.69) ALDH1A1CYP1A2CYP3A4CYP2C9CYP2D6
Hydrochloric Acid SCHEMBL9305520 0.97 MAPK1 (0.71) ALDH1A1CYP1A2CYP3A4CYP2C9CYP2D6
SCHEMBL9302631 0.91 ALDH1A1 (0.58) ALDH1A1CYP1A2CYP3A4CYP2C9CYP2D6
SCHEMBL9434703 0.89 ALDH1A1 (0.55) ALDH1A1CYP1A2CYP3A4CYP2C9CYP2D6
Hydrochloric Acid SCHEMBL9303053 0.88 MAPK1 (0.55) ALDH1A1CYP1A2CYP3A4CYP2C9CYP2D6
SCHEMBL9304013 0.84 ALDH1A1 (0.51) ALDH1A1CYP1A2CYP3A4CYP2C9CYP2D6
Hydrochloric Acid SCHEMBL9305548 0.83 MAPK1 (0.51) ALDH1A1CYP1A2CYP3A4CYP2C9CYP2D6
SCHEMBL9434879 0.83 ALDH1A1 (0.49) ALDH1A1CYP1A2CYP3A4CYP2C9CYP2D6
Linopirdine SCHEMBL122699 0.82 ALDH1A1 (1.00) ALDH1A1CYP1A2CYP3A4CYP2C9CYP2D6
SCHEMBL9839213 0.82 ELANE (0.59) ALDH1A1CYP1A2CYP3A4CYP2C9CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1994006793-A1 3,3'-DISUBSTITUTED-1,3-DIHYDRO-2H-PYRROLO[2,3-b]HETEROCYCLIC-2-ONE USEFUL IN THE TREATMENT OF COGNITIVE DISORDERS OF MAN THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1994-03-31 WO claimed
EP-0660833-A1 3,3'-DISUBSTITUTED-1,3-DIHYDRO-2H-PYRROLO 2,3-b]HETEROCYCLIC-2-ONE USEFUL IN THE TREATMENT OF COGNITIVE DISORDERS OF MAN THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1995-07-05 EP disclosed