Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | F3 | P13726 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9211598 | 1.00 | LMNA (0.53) | LMNATDP1HTTSMN1; SMN2EGFR | |
| SCHEMBL6948703 | 0.85 | HTT (0.60) | LMNATDP1HTTRAB9AMAPK1 | |
| SCHEMBL9211985 | 0.85 | HTT (0.60) | LMNATDP1HTTRAB9AMAPK1 | |
| SCHEMBL6948701 | 0.85 | HTT (0.60) | LMNATDP1HTTRAB9AMAPK1 | |
| SCHEMBL12590207 | 0.83 | HTT (0.60) | LMNATDP1HTTRAB9AMAPK1 | |
| SCHEMBL12888653 | 0.82 | HTT (0.56) | LMNATDP1HTTRAB9AMAPK1 | |
| SCHEMBL9216201 | 0.81 | USP30 (0.36) | LMNATDP1HTTSMN1; SMN2RAB9A | |
| SCHEMBL9216205 | 0.81 | USP30 (0.36) | LMNATDP1HTTSMN1; SMN2RAB9A | |
| SCHEMBL9207159 | 0.77 | HTT (0.55) | LMNATDP1HTTRAB9AGSK3B | |
| SCHEMBL9207163 | 0.77 | HTT (0.55) | LMNATDP1HTTRAB9AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0517103-B1 | Piperidine derivatives, a process for the preparation thereof and the use thereof | 3V SIGMA SPA (IT) | 1995-03-01 | — | — | EP | claimed |
| EP-0517103-A1 | Piperidine derivatives, a process for the preparation thereof and the use thereof | 3V SIGMA S.p.A (IT) | 1992-12-09 | — | — | EP | claimed |