Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.55 |
| ▸ | RELA | Q04206 | 1/20 | 0.55 |
| ▸ | DPP4 | P27487 | 4/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 7/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9210449 | 0.84 | ALDH1A1 (0.42) | NPC1RAB9AHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL5052689 | 0.81 | NPC1 (0.62) | NPC1RAB9AHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL5826439 | 0.81 | DPP4 (0.46) | NPC1RAB9AHPGDSMN1; SMN2HTT | |
| SCHEMBL459359 | 0.79 | MAPT (0.52) | NPC1RAB9AHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL1664978 | 0.79 | NPC1 (0.58) | NPC1RAB9AHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL15191540 | 0.76 | NPC1 (0.56) | NPC1RAB9AHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL15570091 | 0.74 | NPC1 (0.55) | NPC1RAB9AHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL21775472 | 0.74 | MAPT (0.57) | NPC1RAB9AHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL7063800 | 0.74 | RAB9A (0.71) | NPC1RAB9AHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL13258606 | 0.73 | NPC1 (0.67) | NPC1RAB9AHPGDALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0508549-B1 | New triazolopyrimidine and pyrazolopyrimidine derivatives useful for treating cachexia | SANKYO CO (JP) | 1995-04-26 | — | — | EP | disclosed |
| EP-0347252-B1 | METHOD OF TREATING CACHEXIA AND CERTAIN NEW COMPOUNDS FOR USE IN THIS METHOD | SANKYO COMPANY LIMITED (JP) | 1993-05-05 | — | — | EP | disclosed |
| EP-0508549-A2 | New triazolopyrimidine and pyrazolopyrimidine derivatives useful for treating cachexia | SANKYO COMPANY LIMITED (JP) | 1992-10-14 | — | — | EP | disclosed |
| US-5086057-A | METHOD OF TREATING CACHEXIA AND CERTAIN NEW COMPOUNDS FOR USE IN THIS METHOD | SANKYO COMPANY LIMITED (JP) | 1992-02-04 | — | — | US | disclosed |
| US-5055479-A | For enhancing activity of lipoprotein lipase enzymes | SANKYO COMPANY, LIMITED (JP) | 1991-10-08 | — | — | US | disclosed |
| US-4992442-A | Bronchodilator agents | POLA CHEMICAL INDUSTRIES INC., JAPAN (JP) | 1991-02-12 | — | — | US | disclosed |
| EP-0347252-A2 | Method of treating cachexia and certain new compounds for use in this method | SANKYO COMPANY LIMITED (JP) | 1989-12-20 | — | — | EP | disclosed |