Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 6/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6303945 | 0.83 | DHFR (0.48) | DHFR | |
| Hydrochloric Acid SCHEMBL10807714 | 0.82 | DHFR (0.47) | DHFR | |
| SCHEMBL9460324 | 0.78 | DHFR (0.36) | DHFR | |
| SCHEMBL9460321 | 0.78 | DHFR (0.36) | DHFR | |
| SCHEMBL9535789 | 0.78 | ALDH1A1 (0.40) | — | |
| SCHEMBL9535793 | 0.78 | ALDH1A1 (0.40) | — | |
| SCHEMBL9538290 | 0.75 | RARG (0.40) | — | |
| SCHEMBL9538286 | 0.75 | RARG (0.40) | — | |
| SCHEMBL4072522 | 0.75 | DYRK1B (0.46) | DHFRPIK3CAPIK3CG | |
| SCHEMBL9381296 | 0.75 | IDO1 (0.39) | DHFRPIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2104587-A | — | — | None | — | — | JP | disclosed |
| EP-0344922-B1 | N-(N-(tetrahydropyrido(2,3-d)pyrimidinylmethyl)-aminomethylbenzoyl)glutamic acid derivatives | UNIV PRINCETON (US) | 1995-10-18 | — | — | EP | disclosed |
| EP-0344922-A3 | N-(N-(TETRAHYDROPYRIDO(2,3-D)PYRIMIDINYLMETHYL)-AMINOMETHYLBENZOYL)GLUTAMIC ACID DERIVATIVES | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-06-05 | — | — | EP | disclosed |
| JP-H02104587-A | N-(N-(TETRAHYDROPYRIDO(2,3-D)PYRIMIDINYLMETHYL) AMINOMETHYLBENZOYL)GLUTAMIC ACID DERIVATIVE | UNIV PRINCETON | 1990-04-17 | — | — | JP | disclosed |
| EP-0344922-A2 | N-(N-(tetrahydropyrido(2,3-d)pyrimidinylmethyl)-aminomethylbenzoyl)glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-12-06 | — | — | EP | disclosed |
| EP-0344922-A2 | N-(N-(tetrahydropyrido(2,3-d)pyrimidinylmethyl)-aminomethylbenzoyl)glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-12-06 | — | — | EP | disclosed |
| US-4871746-A | N-[N-(tetrahydropyrido[2,3-D]pyrimidinylmethyl)-aminomethylbenzoyl]glutamic acid derivatives as neoplastic growth inhibitors | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-10-03 | — | — | US | disclosed |
| US-4871746-A | N-[N-(tetrahydropyrido[2,3-D]pyrimidinylmethyl)-aminomethylbenzoyl]glutamic acid derivatives as neoplastic growth inhibitors | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-10-03 | — | — | US | disclosed |