Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 12/20 | 0.38 |
| ▸ | CES1 | P23141 | 11/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6829479 | 0.81 | CES2 (0.47) | CES2CES1RAB9ALMNAMAPT | |
| SCHEMBL6671451 | 0.75 | CES2 (0.47) | CES2CES1RAB9ALMNAMAPT | |
| SCHEMBL5948412 | 0.74 | CES2 (0.44) | CES2CES1RAB9ALMNAMAPT | |
| SCHEMBL8601696 | 0.74 | RAB9A (0.44) | CES2CES1RAB9ALMNAMAPT | |
| SCHEMBL830474 | 0.74 | CES2 (0.45) | CES2CES1RAB9ALMNAMAPT | |
| SCHEMBL1520841 | 0.74 | CES2 (0.45) | CES2CES1RAB9ALMNAMAPT | |
| SCHEMBL28159138 | 0.74 | CES2 (0.45) | CES2CES1RAB9ALMNAMAPT | |
| SCHEMBL31120312 | 0.73 | CES2 (0.41) | CES2CES1RAB9ALMNAMAPT | |
| SCHEMBL27496814 | 0.69 | KMT2A (0.36) | LMNAATMGAA | |
| SCHEMBL27513057 | 0.69 | KMT2A (0.35) | RAB9ALMNAMAPTATMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0679157-A1 | NOVEL 3,4-DIARYL THIOPHENES AND ANALOGS THEREOF HAVING USE AS ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1995-11-02 | — | — | EP | disclosed |
| WO-1994015932-A1 | NOVEL 3,4-DIARYL THIOPHENES AND ANALOGS THEREOF HAVING USE AS ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1994-07-21 | — | — | WO | disclosed |