Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | GPR132 | Q9UNW8 | 11/20 | 0.48 |
| ▸ | CMKLR2 | P46091 | 1/20 | 0.48 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.46 |
| ▸ | SENP5 | Q96HI0 | 1/20 | 0.46 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.46 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9216871 | 0.88 | MAPK1 (0.49) | MAPK1ALDH1A1THRBSMN1; SMN2GPR132 | |
| SCHEMBL9211594 | 0.84 | KEAP1 (0.52) | ALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL9213479 | 0.80 | MAPK1 (0.51) | MAPK1ALDH1A1LMNATHRBSMN1; SMN2 | |
| SCHEMBL9217254 | 0.80 | MAPK1 (0.51) | MAPK1ALDH1A1LMNATHRBSMN1; SMN2 | |
| SCHEMBL9209217 | 0.77 | LMNA (0.48) | MAPK1ALDH1A1LMNATHRBSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9210672 | 0.76 | LMNA (0.47) | MAPK1ALDH1A1LMNATHRBSMN1; SMN2 | |
| SCHEMBL9218977 | 0.76 | NPC1 (0.49) | ALDH1A1LMNARAB9A | |
| SCHEMBL9214551 | 0.76 | KMT2A (0.53) | THRBSMN1; SMN2RAB9A | |
| SCHEMBL9214502 | 0.75 | KMT2A (0.61) | ALDH1A1LMNASMN1; SMN2RAB9A | |
| SCHEMBL9216685 | 0.74 | TSHR (0.62) | ALDH1A1LMNASMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0388528-B1 | Carboximidamide derivatives | KIRIN BREWERY (JP) | 1995-09-27 | — | — | EP | claimed |
| US-5223508-A | Hypotensive agents, vasodilators | KIRIN BEER KABUSHIKI KAISHA (JP) | 1993-06-29 | — | — | US | claimed |
| EP-0388528-A2 | Carboximidamide derivatives | KIRIN BEER KABUSHIKI KAISHA (JP) | 1990-09-26 | — | — | EP | claimed |
| EP-0388528-B1 | Carboximidamide derivatives | KIRIN BREWERY (JP) | 1995-09-27 | — | — | EP | disclosed |
| US-5272164-A | Carboximidamide derivatives | KIRIN BEER KABUSHIKI KAISHA (JP) | 1993-12-21 | — | — | US | disclosed |
| US-5223508-A | Hypotensive agents, vasodilators | KIRIN BEER KABUSHIKI KAISHA (JP) | 1993-06-29 | — | — | US | disclosed |
| US-5166347-A | Hypotensive agents, cardiovascular disorders, antiischemic agents and anticoagulants | KIRIN BEER KABUSHIKI KAISHA (JP) | 1992-11-24 | — | — | US | disclosed |
| EP-0388528-A2 | Carboximidamide derivatives | KIRIN BEER KABUSHIKI KAISHA (JP) | 1990-09-26 | — | — | EP | disclosed |