Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHA2 | P29317 | 6/20 | 0.49 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.38 |
| ▸ | P2RX2 | Q9UBL9 | 3/20 | 0.38 |
| ▸ | BUB1 | O43683 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | FHIT | P49789 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9221753 | 0.81 | KDM4E (0.54) | EPHA2EPHB4ERBB2ALDH1A1HSD17B10 | |
| SCHEMBL9211090 | 0.81 | KDM4E (0.54) | EPHA2EPHB4ERBB2ALDH1A1HSD17B10 | |
| SCHEMBL4510923 | 0.77 | EPHA2 (0.54) | EPHA2EPHB4ERBB2DRD4 | |
| SCHEMBL9213959 | 0.76 | EPHA2 (0.48) | EPHA2EPHB4ERBB2ALDH1A1PKM | |
| SCHEMBL28851224 | 0.75 | EPHA2 (0.51) | EPHA2EPHB4ERBB2ALDH1A1BUB1 | |
| SCHEMBL1700442 | 0.75 | EPHA2 (0.51) | EPHA2EPHB4ERBB2PKMKDR | |
| SCHEMBL9214625 | 0.75 | KDM4E (0.56) | ALDH1A1MAPK1HSD17B10KDM4E | |
| SCHEMBL22944175 | 0.75 | EPHA2 (0.52) | EPHA2EPHB4ERBB2KDRP2RX3 | |
| SCHEMBL9213901 | 0.74 | ALDH1A1 (0.50) | EPHA2EPHB4ALDH1A1PKMMAPK1 | |
| SCHEMBL19474639 | 0.74 | EPHA2 (0.49) | EPHA2EPHB4ERBB2CSF1RP2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0411912-B1 | Coumarin derivatives, their preparation and their use in the treatment of cerebrovascular disorders | SANKYO CO (JP) | 1995-04-19 | — | — | EP | disclosed |
| EP-0411912-A2 | Coumarin derivatives, their preparation and their use in the treatment of cerebrovascular disorders | Sankyo Company Limited (JP) | 1991-02-06 | — | — | EP | disclosed |