Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NAMPT | P43490 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9214042 | 1.00 | SMN1; SMN2 (0.40) | SMN1; SMN2NAMPTPOLBHRH4GBA1 | |
| SCHEMBL6377119 | 0.89 | EPHX2 (0.48) | SMN1; SMN2NAMPTHRH4EPHX2TBXA2R | |
| SCHEMBL9214494 | 0.89 | EPHX2 (0.48) | SMN1; SMN2NAMPTHRH4EPHX2TBXA2R | |
| SCHEMBL9211741 | 0.88 | SMN1; SMN2 (0.54) | SMN1; SMN2NAMPTPOLBCYP3A4MAPT | |
| SCHEMBL9211746 | 0.88 | SMN1; SMN2 (0.54) | SMN1; SMN2NAMPTPOLBCYP3A4MAPT | |
| SCHEMBL9214241 | 0.82 | LTA4H (0.45) | SMN1; SMN2NAMPTHRH4EPHX2CYP3A4 | |
| SCHEMBL9211481 | 0.82 | LTA4H (0.45) | SMN1; SMN2NAMPTHRH4EPHX2CYP3A4 | |
| SCHEMBL9211842 | 0.82 | EPHX2 (0.52) | SMN1; SMN2NAMPTHRH4EPHX2TBXA2R | |
| SCHEMBL9211848 | 0.82 | EPHX2 (0.52) | SMN1; SMN2NAMPTHRH4EPHX2TBXA2R | |
| SCHEMBL9502980 | 0.81 | SMN1; SMN2 (0.46) | SMN1; SMN2POLBHRH4TBXA2RTBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0388528-B1 | Carboximidamide derivatives | KIRIN BREWERY (JP) | 1995-09-27 | — | — | EP | disclosed |
| US-5272164-A | Carboximidamide derivatives | KIRIN BEER KABUSHIKI KAISHA (JP) | 1993-12-21 | — | — | US | disclosed |
| US-5223508-A | Hypotensive agents, vasodilators | KIRIN BEER KABUSHIKI KAISHA (JP) | 1993-06-29 | — | — | US | disclosed |
| US-5166347-A | Hypotensive agents, cardiovascular disorders, antiischemic agents and anticoagulants | KIRIN BEER KABUSHIKI KAISHA (JP) | 1992-11-24 | — | — | US | disclosed |
| EP-0388528-A2 | Carboximidamide derivatives | KIRIN BEER KABUSHIKI KAISHA (JP) | 1990-09-26 | — | — | EP | disclosed |