Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | UBE2N | P61088 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 14/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 14/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9214560 | 0.95 | PRMT5 (0.43) | PRMT5WDR77 | |
| Hydrochloric Acid SCHEMBL9211875 | 0.92 | KDM4E (0.42) | KDM4EALDH1A1LMNAUBE2NL3MBTL1 | |
| SCHEMBL9213257 | 0.88 | PRMT5 (0.42) | KDM4EALDH1A1LMNAUBE2NL3MBTL1 | |
| SCHEMBL9742144 | 0.88 | PRMT5 (0.43) | PRMT5WDR77 | |
| Hydrochloric Acid SCHEMBL9213807 | 0.88 | ALDH1A1 (0.40) | KDM4EALDH1A1UBE2NPRMT5WDR77 | |
| Hydrochloric Acid SCHEMBL9215883 | 0.88 | PRMT5 (0.43) | KDM4EALDH1A1LMNAUBE2NL3MBTL1 | |
| SCHEMBL9216594 | 0.84 | PRMT5 (0.39) | PRMT5WDR77 | |
| SCHEMBL9213748 | 0.84 | ABCB1 (0.38) | PRMT5WDR77 | |
| Hydrochloric Acid SCHEMBL9209655 | 0.84 | GRM5 (0.39) | — | |
| Hydrochloric Acid SCHEMBL9741203 | 0.84 | PRMT5 (0.46) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |