Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 4/20 | 0.38 |
| ▸ | GRM5 | P41594 | 2/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 9/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 9/20 | 0.38 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9216594 | 0.98 | PRMT5 (0.39) | ABCB1GRM5PRMT5WDR77SLC6A9 | |
| Hydrochloric Acid SCHEMBL9213807 | 0.94 | ALDH1A1 (0.40) | ABCB1GRM5PRMT5WDR77 | |
| Hydrochloric Acid SCHEMBL9212507 | 0.92 | GRM5 (0.38) | ABCB1GRM5PRMT5WDR77SLC6A9 | |
| SCHEMBL9216938 | 0.91 | PRMT5 (0.40) | GRM5PRMT5WDR77SLC6A9TSHR | |
| Hydrochloric Acid SCHEMBL9208168 | 0.90 | PRMT5 (0.39) | GRM5PRMT5WDR77SLC6A9TSHR | |
| Hydrochloric Acid SCHEMBL9213070 | 0.89 | ADRA1B (0.41) | ABCB1GRM5PRMT5WDR77 | |
| Hydrochloric Acid SCHEMBL9213413 | 0.88 | ADRA1B (0.41) | ABCB1GRM5PRMT5WDR77SLC6A9 | |
| SCHEMBL9214560 | 0.88 | PRMT5 (0.43) | GRM5PRMT5WDR77 | |
| SCHEMBL9740802 | 0.87 | SIGMAR1 (0.45) | GRM5 | |
| SCHEMBL9214376 | 0.84 | KDM4E (0.40) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |