Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BPTF | Q12830 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.56 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.56 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.56 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4794349 | 0.82 | BPTF (0.55) | BPTFKMT2ACHRNB2CHRNA4CHRNB4 | |
| SCHEMBL4775881 | 0.82 | BPTF (0.55) | BPTFKMT2ACHRNB2CHRNA4CHRNB4 | |
| SCHEMBL31104892 | 0.82 | CHRNB2 (0.66) | BPTFKMT2ACHRNB2CHRNA4CHRNB4 | |
| SCHEMBL10756477 | 0.82 | CHRNB2 (0.66) | BPTFKMT2ACHRNB2CHRNA4CHRNB4 | |
| SCHEMBL30426817 | 0.81 | HDAC1 (0.45) | BPTF | |
| SCHEMBL20038332 | 0.81 | HDAC1 (0.42) | BPTFLMNAALDH1A1 | |
| SCHEMBL6350318 | 0.78 | CYP1A2 (0.59) | BPTFKMT2ACHRNB2CHRNA4CHRNB4 | |
| SCHEMBL2246752 | 0.77 | ACVR1 (0.49) | LMNAALDH1A1 | |
| SCHEMBL3272049 | 0.77 | HTR3E (0.62) | KMT2ACYP1A2LMNAMEN1ALDH1A1 | |
| SCHEMBL5269599 | 0.77 | ACVR1 (0.49) | LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0320032-B1 | Pyridizinamine derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1995-01-18 | — | — | EP | disclosed |
| US-5231184-A | Viricide intermediate | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-07-27 | — | — | US | disclosed |
| US-5106973-A | Viricide intermediates | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-04-21 | — | — | US | disclosed |
| US-4992433-A | Viricides | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-02-12 | — | — | US | disclosed |
| EP-0320032-A1 | Pyridizinamine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-06-14 | — | — | EP | disclosed |
| EP-0211457-A2 | Novel (4-substituted-piperazinyl)pyridazines | JANSSEN PHARMACEUTICA N.V. (BE) | 1987-02-25 | — | — | EP | disclosed |