Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14191673 | 0.91 | NR1I2 (0.48) | MAPTKDM4ELMNANPSR1RXFP1 | |
| SCHEMBL10588331 | 0.88 | MEN1 (0.49) | MAPTKDM4ELMNANPSR1RXFP1 | |
| SCHEMBL10588330 | 0.88 | MEN1 (0.49) | MAPTKDM4ELMNANPSR1RXFP1 | |
| Pirodavir SCHEMBL146440 | 0.80 | HRH3 (0.46) | MAPTKDM4ELMNANPSR1RXFP1 | |
| SCHEMBL9209675 | 0.80 | HRH3 (0.44) | MAPTKDM4ELMNANPSR1RXFP1 | |
| SCHEMBL9220549 | 0.79 | HRH3 (0.45) | MAPTKDM4ELMNANPSR1RXFP1 | |
| SCHEMBL27574704 | 0.79 | CYP2C9 (0.54) | MAPTHRH3KMT2AKCNH2PARP15 | |
| SCHEMBL9209752 | 0.78 | HRH3 (0.44) | MAPTKDM4ELMNANPSR1RXFP1 | |
| SCHEMBL9218863 | 0.78 | HRH3 (0.44) | MAPTKDM4ELMNANPSR1RXFP1 | |
| SCHEMBL9220790 | 0.77 | MEN1 (0.47) | MAPTKDM4ELMNANPSR1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0320032-B1 | Pyridizinamine derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1995-01-18 | — | — | EP | disclosed |
| US-5231184-A | Viricide intermediate | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-07-27 | — | — | US | disclosed |
| US-5106973-A | Viricide intermediates | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-04-21 | — | — | US | disclosed |
| US-4992433-A | Viricides | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-02-12 | — | — | US | disclosed |
| EP-0320032-A1 | Pyridizinamine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-06-14 | — | — | EP | disclosed |