Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15894653 | 0.82 | CYP1A2 (0.39) | CYP1A2CYP2C19KMT2ALMNAHTR2A | |
| SCHEMBL9207448 | 0.77 | KDM4E (0.39) | KDM4EPKMCA1CA2HTR2A | |
| SCHEMBL9207434 | 0.77 | KDM4E (0.39) | KDM4EPKMCA1CA2HTR2A | |
| SCHEMBL28341268 | 0.76 | KDM4E (0.38) | KDM4EPKMCYP1A2CYP2C19KMT2A | |
| SCHEMBL7326617 | 0.72 | KDM4E (0.56) | KDM4EPKMCYP1A2CYP2C19KMT2A | |
| SCHEMBL31520302 | 0.72 | PARP1 (0.36) | CA1CA2 | |
| SCHEMBL258234 | 0.72 | PARP1 (0.36) | CA1CA2 | |
| SCHEMBL19130238 | 0.68 | SIGMAR1 (0.43) | LMNA | |
| SCHEMBL15894662 | 0.68 | SIGMAR1 (0.43) | LMNA | |
| SCHEMBL17295965 | 0.68 | SIGMAR1 (0.43) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0319073-B1 | Cyclo-octane neuroprotective agents | MERCK SHARP & DOHME (GB) | 1995-08-23 | — | — | EP | disclosed |
| US-4927819-A | ANTICONVULSANT, PREVENTION OF NEURODEGENERATIVE DISORDERS | MERCK SHARP & DOHME LIMITED (GB) | 1990-05-22 | — | — | US | disclosed |
| EP-0319073-A2 | Cyclo-octane neuroprotective agents | MERCK SHARP & DOHME LTD. (GB) | 1989-06-07 | — | — | EP | disclosed |