Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.40 |
| ▸ | ADH1C | P00326 | 1/20 | 0.36 |
| ▸ | ADH1A | P07327 | 1/20 | 0.36 |
| ▸ | ADH4 | P08319 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.31 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9753953 | 0.86 | OPRM1 (0.42) | OPRM1TRPM8TRPA1ADH1CADH1A | |
| Hydrochloric Acid SCHEMBL14320260 | 0.76 | OPRM1 (0.33) | OPRM1TRPM8TRPA1ALDH1A1 | |
| SCHEMBL31105805 | 0.74 | TRPM8 (0.48) | OPRM1TRPM8TRPA1EPHX1ALDH1A1 | |
| SCHEMBL6869088 | 0.74 | EPHX1 (0.51) | OPRM1TRPM8TRPA1ADH1CADH1A | |
| SCHEMBL8038624 | 0.73 | OPRM1 (0.34) | OPRM1TRPM8TRPA1EPHX1 | |
| SCHEMBL5307491 | 0.73 | TRPM8 (0.47) | OPRM1TRPM8TRPA1EPHX1ALDH1A1 | |
| SCHEMBL6870235 | 0.72 | EPHX1 (0.49) | OPRM1TRPM8TRPA1ADH1CADH1A | |
| SCHEMBL584442 | 0.72 | EPHX1 (0.39) | OPRM1TRPM8TRPA1EPHX1 | |
| Menthol SCHEMBL27673361 | 0.71 | TRPM8 (0.78) | OPRM1TRPM8TRPA1EPHX1ALDH1A1 | |
| SCHEMBL5307624 | 0.70 | TRPM8 (0.44) | OPRM1TRPM8TRPA1EPHX1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510028-B1 | THIOFORMAMIDE DERIVATIVES | RHONE POULENC RORER SA (FR) | 1995-03-15 | — | — | EP | disclosed |
| US-5364853-A | Treatment of disorders associated with vascular, respiratory, gastrointestinal tract, urinary bladder or uterus smooth muscle contraction | RHONE-POULENC RORER LIMITED (GB) | 1994-11-15 | — | — | US | disclosed |
| EP-0377532-B1 | THIOFORMAMIDE DERIVATIVES | MAY AND BAKER LIMITED (GB) | 1992-07-29 | — | — | EP | disclosed |
| US-5104883-A | Cardiovascular, respiratory, gastrointestirol, urogenital disorders; baldness; premature labor | MAY & BAKER LIMITED (GB) | 1992-04-14 | — | — | US | disclosed |
| EP-0377532-A1 | Thioformamide derivatives | MAY AND BAKER LIMITED (GB) | 1990-07-11 | — | — | EP | disclosed |