Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8871550 | 0.91 | KDM4E (0.54) | GAAKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL9370493 | 0.87 | SMN1; SMN2 (0.47) | GAAKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL14337077 | 0.85 | KDM4E (0.47) | GAAKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL8872114 | 0.82 | KDM4E (0.66) | GAAKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL19617145 | 0.81 | MEN1 (0.47) | GAAKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL2471369 | 0.81 | LTA4H (0.48) | GAAKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL28976959 | 0.81 | ALDH1A1 (0.58) | GAAKDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL13092478 | 0.81 | LTA4H (0.48) | GAAKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL2873641 | 0.81 | SMN1; SMN2 (0.43) | GAAKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL2471930 | 0.81 | SMN1; SMN2 (0.43) | GAAKDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5470859-A | Cognition activators for the central nervous system | BEECHAM GROUP P.L.C. (GB) | 1995-11-28 | — | — | US | disclosed |
| EP-0414394-B1 | Azabicyclic Derivatives having muscarinic receptor affinity | BEECHAM GROUP PLC (GB) | 1995-07-05 | — | — | EP | disclosed |
| US-5217975-A | AZABICYCLIC COMPOUNDS FOR TREATING DEMENTIA | BEECHAM GROUP P.L.C. (GB) | 1993-06-08 | — | — | US | disclosed |
| EP-0414394-A2 | Azabicyclic Derivatives having muscarinic receptor affinity | BEECHAM GROUP PLC (GB) | 1991-02-27 | — | — | EP | disclosed |
| EP-0402056-A2 | Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them | Beecham Group p.l.c. (GB) | 1990-12-12 | — | — | EP | disclosed |