Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 7/20 | 0.43 |
| ▸ | THRB | P10828 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9220263 | 0.95 | TP53 (0.46) | MAPTTP53THRBKDM4EGAA | |
| SCHEMBL9220478 | 0.94 | MAPT (0.42) | MAPTTP53THRBKDM4EGAA | |
| SCHEMBL9215158 | 0.91 | MAPT (0.43) | MAPTTP53THRBKDM4EGAA | |
| SCHEMBL9218757 | 0.89 | TP53 (0.42) | MAPTTP53THRBKDM4EGAA | |
| SCHEMBL9213248 | 0.88 | KMT2A (0.40) | LMNASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL9218677 | 0.84 | L3MBTL1 (0.39) | MAPTTP53THRBKDM4EGAA | |
| SCHEMBL9213879 | 0.83 | L3MBTL1 (0.39) | MAPTTP53THRBGAASMN1; SMN2 | |
| SCHEMBL9221161 | 0.83 | L3MBTL1 (0.38) | MAPTTP53THRBGAASMN1; SMN2 | |
| SCHEMBL5500482 | 0.83 | MEN1 (0.44) | MAPTTP53THRBKDM4ELMNA | |
| SCHEMBL9218854 | 0.82 | PTPN1 (0.40) | MAPTGAASMN1; SMN2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0512570-B1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-10-11 | — | — | EP | disclosed |
| EP-0512570-A1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-11 | — | — | EP | disclosed |