Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | THRB | P10828 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9215360 | 0.95 | MAPT (0.43) | TP53MAPTTHRBMEN1MAPK1 | |
| SCHEMBL9220478 | 0.95 | MAPT (0.42) | TP53MAPTTHRBMAPK1GAA | |
| SCHEMBL9215158 | 0.94 | MAPT (0.43) | TP53MAPTTHRBMAPK1GAA | |
| SCHEMBL9218757 | 0.92 | TP53 (0.42) | TP53MAPTTHRBMAPK1GAA | |
| SCHEMBL9213879 | 0.88 | L3MBTL1 (0.39) | TP53MAPTTHRBMEN1MAPK1 | |
| SCHEMBL5500482 | 0.88 | MEN1 (0.44) | TP53MAPTTHRBMEN1KMT2A | |
| SCHEMBL9218677 | 0.88 | L3MBTL1 (0.39) | TP53MAPTTHRBMEN1MAPK1 | |
| SCHEMBL9215129 | 0.87 | L3MBTL1 (0.41) | TP53MAPTTHRBMEN1KMT2A | |
| SCHEMBL9215732 | 0.87 | EGFR (0.38) | TP53MAPTTHRBMEN1MAPK1 | |
| SCHEMBL9683150 | 0.86 | HTT (0.47) | TP53MAPTTHRBMEN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0512570-B1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-10-11 | — | — | EP | disclosed |
| EP-0512570-A1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-11 | — | — | EP | disclosed |