Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | SLC5A2 | P31639 | 2/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.35 |
| ▸ | CTRC | Q99895 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL941277 | 0.94 | KCNH2 (0.47) | ALDH1A1KCNH2SLC5A2CYP19A1GABRA2 | |
| SCHEMBL8551658 | 0.92 | KCNH2 (0.50) | ALDH1A1KCNH2SLC5A2CYP19A1GABRA2 | |
| SCHEMBL9850641 | 0.92 | KCNH2 (0.50) | ALDH1A1KCNH2SLC5A2CYP19A1GABRA2 | |
| SCHEMBL3182612 | 0.87 | ALDH1A1 (0.48) | ALDH1A1SLC5A2NOS2CYP19A1GABRA2 | |
| SCHEMBL19009143 | 0.82 | KCNH2 (0.45) | KCNH2SLC5A2NOS2CYP19A1GABRA2 | |
| SCHEMBL27602446 | 0.81 | KCNH2 (0.41) | KCNH2SLC5A2NOS2CYP19A1GABRA2 | |
| SCHEMBL12356537 | 0.80 | KCNH2 (0.59) | ALDH1A1KCNH2CYP19A1MIF | |
| SCHEMBL4592210 | 0.79 | ALDH1A1 (0.46) | ALDH1A1SLC5A2GAAMAPT | |
| SCHEMBL10843908 | 0.78 | CYP1A2 (0.38) | ALDH1A1MEN1KMT2AGAAMAPT | |
| SCHEMBL10843918 | 0.78 | CYP1A2 (0.38) | ALDH1A1MEN1KMT2AGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0320032-B1 | Pyridizinamine derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1995-01-18 | — | — | EP | disclosed |
| CN-1021328-C | PROCESS FOR PREPARING PYRIDAZINAMINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 1993-06-23 | — | — | CN | disclosed |
| US-5106973-A | Viricide intermediates | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-04-21 | — | — | US | disclosed |
| US-4992433-A | Viricides | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-02-12 | — | — | US | disclosed |
| EP-0320032-A1 | Pyridizinamine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-06-14 | — | — | EP | disclosed |
| CN-1033274-A | The preparation method of new Pyridazinyl amine derivative | JANSSEN PHARMACEUTICA NV (BE) | 1989-06-07 | — | — | CN | disclosed |