Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | CTH | P32929 | 1/20 | 0.35 |
| ▸ | CBS | P35520 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | PAM | P19021 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL575181 | 0.84 | ALDH1A1 (0.40) | TSHRALDH1A1 | |
| SCHEMBL3182447 | 0.82 | TSHR (0.47) | TSHRCTHCBSTHPOTHRB | |
| SCHEMBL21611838 | 0.80 | TSHR (0.38) | TSHRCTHCBSTHPOTHRB | |
| SCHEMBL10495649 | 0.79 | TSHR (0.45) | TSHRCTHCBSTHPOTHRB | |
| SCHEMBL575094 | 0.77 | — | — | |
| SCHEMBL11530469 | 0.76 | ALDH1A1 (0.35) | TSHRALDH1A1 | |
| SCHEMBL9212802 | 0.76 | TSHR (0.35) | TSHRCTHCBSTHPOTHRB | |
| SCHEMBL11060272 | 0.76 | — | — | |
| SCHEMBL15180219 | 0.75 | TSHR (0.41) | TSHRALDH1A1 | |
| SCHEMBL9303937 | 0.74 | SOAT1 (0.46) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0681580-A1 | PRODRUGS OF ANTIINFLAMMATORY 3-ACYL-2-OXINDOLE-1-CARBOXAMIDES. | PFIZER HOSPITAL PROD (US) | 1995-11-15 | — | — | EP | disclosed |
| WO-1994017061-A1 | PRODRUGS OF ANTIINFLAMMATORY 3-ACYL-2-OXINDOLE-1-CARBOXAMIDES | PFIZER INC. (US) | 1994-08-04 | — | — | WO | disclosed |