Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NAAA | Q02083 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9218992 | 0.89 | HDAC1 (0.50) | NPC1RAB9AHDAC1HDAC2L3MBTL1 | |
| SCHEMBL9220337 | 0.85 | L3MBTL1 (0.49) | NPC1RAB9AHDAC1HDAC2L3MBTL1 | |
| SCHEMBL9430499 | 0.84 | TP53 (0.50) | NPC1RAB9AL3MBTL1TDP1CNR1 | |
| SCHEMBL9213682 | 0.84 | TP53 (0.50) | NPC1RAB9AL3MBTL1TDP1CNR1 | |
| SCHEMBL9219544 | 0.84 | TP53 (0.50) | NPC1RAB9AL3MBTL1TDP1CNR1 | |
| SCHEMBL9212386 | 0.83 | L3MBTL1 (0.52) | NPC1RAB9AHDAC1HDAC2L3MBTL1 | |
| SCHEMBL9431631 | 0.83 | L3MBTL1 (0.52) | NPC1RAB9AHDAC1HDAC2L3MBTL1 | |
| SCHEMBL9215785 | 0.83 | L3MBTL1 (0.44) | NPC1RAB9AHDAC1HDAC2L3MBTL1 | |
| SCHEMBL9218047 | 0.82 | TP53 (0.51) | NPC1RAB9AL3MBTL1TDP1CNR1 | |
| SCHEMBL9430225 | 0.82 | NPC1 (0.50) | NPC1RAB9AHDAC1HDAC2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0512570-B1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-10-11 | — | — | EP | disclosed |
| EP-0512570-A1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-11 | — | — | EP | disclosed |