Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | NAAA | Q02083 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 4/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9212386 | 0.93 | L3MBTL1 (0.52) | L3MBTL1NAAANPC1RAB9ATP53 | |
| SCHEMBL9431631 | 0.93 | L3MBTL1 (0.52) | L3MBTL1NAAANPC1RAB9ATP53 | |
| SCHEMBL9430225 | 0.92 | NPC1 (0.50) | L3MBTL1NPC1RAB9ATP53HDAC1 | |
| SCHEMBL9216809 | 0.90 | NAAA (0.49) | NAAATP53ALOX15HDAC1HDAC2 | |
| SCHEMBL9213682 | 0.89 | TP53 (0.50) | L3MBTL1NPC1RAB9ATP53TDP1 | |
| SCHEMBL9430499 | 0.89 | TP53 (0.50) | L3MBTL1NPC1RAB9ATP53TDP1 | |
| SCHEMBL9219544 | 0.89 | TP53 (0.50) | L3MBTL1NPC1RAB9ATP53TDP1 | |
| SCHEMBL9431228 | 0.89 | NPC1 (0.51) | L3MBTL1NPC1RAB9ATP53ALDH1A1 | |
| SCHEMBL9212117 | 0.89 | TP53 (0.51) | L3MBTL1NPC1RAB9ATP53ALDH1A1 | |
| SCHEMBL9218047 | 0.88 | TP53 (0.51) | L3MBTL1NPC1RAB9ATP53ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0512570-B1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-10-11 | — | — | EP | disclosed |
| CN-1067886-A | New urea derivatives, their preparation method and pharmaceutical composition thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1993-01-13 | — | — | CN | disclosed |
| EP-0512570-A1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-11 | — | — | EP | disclosed |