Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9220800 | 0.84 | CYP11B1 (0.50) | KMT2AL3MBTL1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL9220414 | 0.83 | S1PR1 (0.40) | MEN1KMT2AGAARAB9AALDH1A1 | |
| SCHEMBL9159335 | 0.80 | MAOA (0.45) | GAARAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL9159339 | 0.80 | MAOA (0.45) | GAARAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL2622583 | 0.78 | CYP11B1 (0.49) | MEN1KMT2AGAARAB9AALDH1A1 | |
| SCHEMBL14102672 | 0.76 | CYP11B2 (0.58) | CYP11B1CYP11B2SMN1; SMN2AHRCYP19A1 | |
| SCHEMBL9621234 | 0.74 | TP53 (0.44) | MEN1KMT2AGAARAB9AALDH1A1 | |
| SCHEMBL14049206 | 0.72 | CYP11B1 (0.44) | MEN1KMT2AGAARAB9AALDH1A1 | |
| SCHEMBL10071518 | 0.70 | HRH3 (0.55) | MEN1KMT2AGAARAB9AALDH1A1 | |
| SCHEMBL12085703 | 0.70 | MEN1 (0.52) | MEN1KMT2AGAARAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0524517-B1 | Substituted 3,4-dihydronaphthalenes, medicament containing them and process for their preparation | GRUENENTHAL GMBH (DE) | 1995-06-21 | — | — | EP | disclosed |
| US-5254731-A | Enzyme inhibitors; leukotriene disorders | GRUENENTHAL GMBH (DE) | 1993-10-19 | — | — | US | disclosed |
| EP-0524517-A1 | Substituted 3,4-dihydronaphthalenes, medicament containing them and process for their preparation | Grünenthal GmbH (DE) | 1993-01-27 | — | — | EP | disclosed |