Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | TOP1 | P11387 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | TOP2A | P11388 | 1/20 | 0.32 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9212047 | 0.92 | TOP1 (0.39) | CYP3A4CYP2C9TOP1ALDH1A1POLB | |
| SCHEMBL9210690 | 0.90 | EPHA2 (0.40) | CYP3A4CYP2C9TOP1ALDH1A1POLB | |
| SCHEMBL9147432 | 0.89 | CYP3A4 (0.51) | CYP3A4CYP2C9TOP1ALDH1A1POLB | |
| SCHEMBL9147426 | 0.89 | CYP3A4 (0.51) | CYP3A4CYP2C9TOP1ALDH1A1POLB | |
| SCHEMBL9209315 | 0.84 | ALDH1A1 (0.54) | CYP3A4CYP2C9ALDH1A1POLBCHRM2 | |
| SCHEMBL9209326 | 0.83 | KDM4E (0.42) | CYP3A4CYP2C9TOP1ALDH1A1POLB | |
| SCHEMBL9217756 | 0.81 | EPHA2 (0.42) | TOP1ALDH1A1POLBLMNAKMT2A | |
| SCHEMBL9212148 | 0.81 | EPHA2 (0.42) | TOP1ALDH1A1POLBLMNAKMT2A | |
| SCHEMBL9213760 | 0.81 | LMNA (0.50) | TOP1ALDH1A1POLBPIM1LMNA | |
| SCHEMBL9146453 | 0.81 | PIM1 (0.49) | CYP3A4CYP2C9TOP1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0388298-B1 | Derivatives of pyridone carboxylic acids substituted by an azetidine, their preparation and their use as medicines | ESTEVE LABOR DR (ES) | 1995-06-21 | — | — | EP | claimed |