Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDAH1 | O94760 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 3/20 | 0.36 |
| ▸ | MAOB | P27338 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PTGIR | P43119 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4366554 | 0.75 | MEN1 (0.43) | DDAH1NOS1 | |
| SCHEMBL7354050 | 0.72 | DDAH1 (0.78) | DDAH1NOS1MAOAMAOBALDH1A1 | |
| SCHEMBL121708 | 0.71 | NOTUM (0.50) | ALDH1A1MAPTSMN1; SMN2HSD17B10MAPK1 | |
| SCHEMBL2561310 | 0.71 | — | — | |
| Diphenylsulfane SCHEMBL11466727 | 0.71 | HPGD (0.53) | DDAH1NOS1MAOAMAOBALDH1A1 | |
| Diphenylsulfane SCHEMBL27714827 | 0.71 | HPGD (0.60) | DDAH1NOS1MAOAMAOBALDH1A1 | |
| Diphenylsulfane SCHEMBL28332331 | 0.71 | HPGD (0.60) | DDAH1NOS1MAOAMAOBALDH1A1 | |
| Diphenylsulfane SCHEMBL27611905 | 0.71 | HPGD (0.60) | DDAH1NOS1MAOAMAOBALDH1A1 | |
| Diphenylsulfane SCHEMBL452 | 0.71 | HPGD (0.60) | DDAH1NOS1MAOAMAOBALDH1A1 | |
| Diphenylsulfane SCHEMBL7109540 | 0.71 | HPGD (0.60) | DDAH1NOS1MAOAMAOBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0269859-B2 | Pyrazolotriazine compounds | OTSUKA PHARMA CO LTD (JP) | 1995-10-18 | — | — | EP | disclosed |
| US-4824834-A | TREATING GOUT | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1989-04-25 | — | — | US | disclosed |
| EP-0269859-A2 | Pyrazolotriazine compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-06-08 | — | — | EP | disclosed |