Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 8/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9220205 | 0.79 | SLC6A2 (0.30) | OPRM1SLC6A4SLC6A2 | |
| SCHEMBL9046586 | 0.79 | CA12 (0.32) | OPRM1SLC6A4SLC6A2 | |
| SCHEMBL9214375 | 0.79 | OPRM1 (0.48) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 | |
| SCHEMBL9227964 | 0.77 | OPRM1 (0.46) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 | |
| SCHEMBL9228922 | 0.77 | OPRM1 (0.46) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 | |
| SCHEMBL9226485 | 0.75 | OPRM1 (0.39) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 | |
| SCHEMBL9209049 | 0.75 | OPRM1 (0.39) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 | |
| SCHEMBL9226479 | 0.75 | OPRM1 (0.39) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 | |
| SCHEMBL9224997 | 0.74 | ALOX5 (0.64) | — | |
| SCHEMBL9048013 | 0.73 | CHRNA1 (0.33) | SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0385662-B1 | Heterocycles with inhibitory activity of 5-lipoxygenase | ZENECA LTD (GB) | 1995-12-13 | — | — | EP | disclosed |
| US-5403859-A | PHENYLENE-CYCLIC ETHER COMPOUNDS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-04-04 | — | — | US | disclosed |
| US-5401751-A | Enzyme inhibitors for 5-lipoxygenase | ZENECA LIMITED (GB) | 1995-03-28 | — | — | US | disclosed |
| EP-0375404-B1 | Heterocyclic derivatives | ICI PLC (GB) | 1994-02-09 | — | — | EP | disclosed |
| US-5236919-A | Inhibitorsof enzyme 5-lipoxygenase | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-08-17 | — | — | US | disclosed |
| US-5134148-A | Heterocycles for use as inhibitors of leukotrienes | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-07-28 | — | — | US | disclosed |
| US-5098930-A | Inhibitors of lipoxygenase for treatment of diseases mediated with leukotrienes | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-03-24 | — | — | US | disclosed |
| EP-0385662-A2 | Heterocycles with inhibitory activity of 5-lipoxygenase | ZENECA LIMITED (GB) | 1990-09-05 | — | — | EP | disclosed |
| EP-0375404-A2 | Heterocyclic derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-06-27 | — | — | EP | disclosed |