SCHEMBL9218264

SCHEMBL9218264

[O-][n+]1cccc(CCCc2ccccc2)c1

nearest known ligand 0.74

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GPR84 Q9NQS5 18/20 0.74
HTR2A P28223 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10390039 0.92 GPR84 (0.62) GPR84
SCHEMBL9321427 0.82 GPR84 (0.62) GPR84
SCHEMBL9623730 0.82 GPR84 (0.67) GPR84
SCHEMBL4769799 0.81 GPR84 (0.54) GPR84
SCHEMBL2259203 0.81 GPR84 (0.50) GPR84HTR2A
SCHEMBL10985187 0.79 GPR84 (0.58) GPR84
SCHEMBL9440118 0.79 GPR84 (0.58) GPR84
SCHEMBL8124865 0.79 CALM1 (0.52) GPR84
SCHEMBL4770503 0.78 GPR84 (0.57) GPR84
SCHEMBL2867974 0.78 GPR84 (0.56) GPR84

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0535152-B1 Bis-benzo or benzopyrido cyclo hepta piperidene, piperidylene and piperazine compounds as PAF antagonists and compositions thereof. SCHERING CORP (US) 1995-08-09 EP disclosed
US-5422351-A Antiallergens; antiinflammatory agents SCHERING CORPORATION (US) 1995-06-06 US disclosed
EP-0341860-B1 Benzopyrido piperidine, piperidylidene and piperazine compounds, compositions, methods of manufacture and methods of use SCHERING CORP (US) 1994-07-13 EP disclosed
US-5104876-A Antiallergens, antiinflammatory agent SCHERING CORPORATION 1992-04-14 US disclosed
WO-1992000293-A1 BIS-BENZO OR BENZOPYRIDO CYCLO HEPTA PIPERIDENE, PIPERIDYLIDENE AND PIPERAZINE COMPOUNDS AND COMPOSITIONS SCHERING CORPORATION (US) 1992-01-09 WO disclosed
EP-0411048-A1 NOVEL BENZOPYRIDO PIPERIDINE, PIPERIDYLIDENE AND PIPERAZINE COMPOUNDS, COMPOSITIONS, METHODS OF MANUFACTURE AND METHODS OF USE SCHERING CORPORATION (US) 1991-02-06 EP disclosed
EP-0341860-A1 Benzopyrido piperidine, piperidylidene and piperazine compounds, compositions, methods of manufacture and methods of use SCHERING CORPORATION (US) 1989-11-15 EP disclosed
WO-1989010369-A1 NOVEL BENZOPYRIDO PIPERIDINE, PIPERIDYLIDENE AND PIPERAZINE COMPOUNDS, COMPOSITIONS, METHODS OF MANUFACTURE AND METHODS OF USE SCHERING CORPORATION (US) 1989-11-02 WO disclosed