Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 4/20 | 0.67 |
| ▸ | HTR1A | P08908 | 3/20 | 0.67 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.67 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 7/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 5/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.34 |
| ▸ | HTR2B | P41595 | 3/20 | 0.34 |
| ▸ | NR2E1 | Q9Y466 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HTR2A | P28223 | 3/20 | 0.34 |
| ▸ | HTR2C | P28335 | 3/20 | 0.34 |
| ▸ | HTR6 | P50406 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | SCN1A | P35498 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9120261 | 0.84 | HTR1A (0.58) | SLC6A4HTR1AADRA2ASLC6A2TSHR | |
| SCHEMBL9123064 | 0.84 | HTR1A (0.67) | SLC6A4HTR1AADRA2ASLC6A2LMNA | |
| SCHEMBL9120892 | 0.83 | HTR1A (0.60) | SLC6A4HTR1AADRA2ASLC6A2ABCB1 | |
| Tertatolol SCHEMBL6513139 | 0.80 | HTR1A (1.00) | SLC6A4HTR1AADRA2ASLC6A2LMNA | |
| Tertatolol SCHEMBL49635 | 0.80 | HTR1A (1.00) | SLC6A4HTR1AADRA2ASLC6A2LMNA | |
| Tertatolol SCHEMBL49634 | 0.80 | HTR1A (1.00) | SLC6A4HTR1AADRA2ASLC6A2LMNA | |
| Tertatolol SCHEMBL23234262 | 0.80 | HTR1A (0.98) | SLC6A4HTR1AADRA2ASLC6A2LMNA | |
| Tertatolol SCHEMBL388069 | 0.80 | HTR1A (0.98) | SLC6A4HTR1AADRA2ASLC6A2LMNA | |
| Tertatolol SCHEMBL365413 | 0.80 | HTR1A (0.98) | SLC6A4HTR1AADRA2ASLC6A2LMNA | |
| SCHEMBL9507435 | 0.79 | SLC6A2 (0.70) | SLC6A4HTR1AADRA2ASLC6A2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0571243-B1 | Thiochromane derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1995-07-26 | — | — | EP | disclosed |
| EP-0571243-A1 | Thiochromane derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1993-11-24 | — | — | EP | disclosed |