Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9219445 | 0.84 | SLC6A4 (0.67) | HTR1AADRA2ASLC6A2SLC6A4TSHR | |
| SCHEMBL8317904 | 0.79 | HTR1A (0.51) | HTR1AADRA2ASLC6A2SLC6A4L3MBTL1 | |
| SCHEMBL9123064 | 0.76 | HTR1A (0.67) | HTR1AADRA2ASLC6A2SLC6A4TSHR | |
| SCHEMBL9120892 | 0.75 | HTR1A (0.60) | HTR1AADRA2ASLC6A2SLC6A4TSHR | |
| SCHEMBL9122776 | 0.74 | LMNA (0.49) | HTR1AADRA2ASLC6A2SLC6A4TSHR | |
| SCHEMBL7524469 | 0.73 | HTR1A (0.51) | HTR1AADRA2ASLC6A2SLC6A4L3MBTL1 | |
| SCHEMBL7524020 | 0.73 | HTR1A (0.51) | HTR1AADRA2ASLC6A2SLC6A4L3MBTL1 | |
| Tertatolol SCHEMBL49634 | 0.73 | HTR1A (1.00) | HTR1AADRA2ASLC6A2SLC6A4TSHR | |
| Tertatolol SCHEMBL49635 | 0.73 | HTR1A (1.00) | HTR1AADRA2ASLC6A2SLC6A4TSHR | |
| Tertatolol SCHEMBL6513139 | 0.73 | HTR1A (1.00) | HTR1AADRA2ASLC6A2SLC6A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0571243-B1 | Thiochromane derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1995-07-26 | — | — | EP | disclosed |
| US-5389668-A | Thiochroman compounds | ADIR ET COMPAGNIE (FR) | 1995-02-14 | — | — | US | disclosed |
| US-5385930-A | Treating central nervous system disorders like anxiety and depression | ADIR ET COMPAGNIE (FR) | 1995-01-31 | — | — | US | disclosed |
| US-5371103-A | Thiochroman compounds | ADIR ET COMPAGNIE (FR) | 1994-12-06 | — | — | US | disclosed |
| US-5332741-A | Antidepressants | ADIR ET COMPAGNIE (FR) | 1994-07-26 | — | — | US | disclosed |
| EP-0571243-A1 | Thiochromane derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1993-11-24 | — | — | EP | disclosed |