Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 8/20 | 0.42 |
| ▸ | CSNK2B | P67870 | 8/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 8/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9219495 | 0.82 | MCL1 (0.60) | DHODHMCL1NPC1RAB9ATP53 | |
| SCHEMBL9210201 | 0.80 | MCL1 (0.57) | DHODHMCL1NPC1RAB9ACSNK2A2 | |
| SCHEMBL8197213 | 0.79 | MCL1 (0.43) | MCL1RAB9ACSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL9212636 | 0.78 | TP53 (0.49) | NPC1RAB9ATP53 | |
| SCHEMBL9220313 | 0.77 | MCL1 (0.57) | DHODHMCL1NPC1RAB9ACSNK2A2 | |
| SCHEMBL9219621 | 0.76 | CSNK2A2 (0.46) | DHODHMCL1NPC1RAB9ACSNK2A2 | |
| SCHEMBL9220492 | 0.74 | MCL1 (0.65) | DHODHMCL1NPC1RAB9ACSNK2A2 | |
| SCHEMBL9219841 | 0.73 | MCL1 (0.63) | MCL1 | |
| SCHEMBL27935154 | 0.72 | MCL1 (0.45) | MCL1CSNK2A2CSNK2BCSNK2A1MAPT | |
| SCHEMBL4710225 | 0.72 | TP53 (0.51) | DHODHMCL1TP53MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0512570-B1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-10-11 | — | — | EP | disclosed |
| CN-1067886-A | New urea derivatives, their preparation method and pharmaceutical composition thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1993-01-13 | — | — | CN | disclosed |
| EP-0512570-A1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-11 | — | — | EP | disclosed |