SCHEMBL9219901

SCHEMBL9219901

CCCCC=C[Si](C)(C)c1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MGAM O43451 1/20 0.39
CYP1A2 P05177 5/20 0.36
CYP3A4 P08684 4/20 0.36
CYP2C9 P11712 4/20 0.36
TSHR P16473 4/20 0.36
CYP2C19 P33261 4/20 0.36
ALDH1A1 P00352 2/20 0.36
FAAH O00519 5/20 0.36
CES1 P23141 3/20 0.36
SOAT2 O75908 1/20 0.36
SOAT1 P35610 1/20 0.36
CYP2D6 P10635 3/20 0.35
KDM4E B2RXH2 1/20 0.35
HSD17B10 Q99714 1/20 0.35
EPHX2 P34913 1/20 0.34
BID P55957 3/20 0.33
BCL2L1 Q07817 3/20 0.33
MCL1 Q07820 3/20 0.33
BAK1 Q16611 3/20 0.33
SMN1; SMN2 Q16637 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9219897 1.00 MGAM (0.39) MGAMCYP1A2CYP3A4CYP2C9TSHR
SCHEMBL2965524 0.81 TSHR (0.34) CYP1A2CYP3A4CYP2C9TSHRCYP2C19
SCHEMBL21383438 0.80 CYP1A2 (0.35) CYP1A2CYP3A4CYP2C9TSHRCYP2C19
SCHEMBL21383346 0.80 CYP1A2 (0.35) CYP1A2CYP3A4CYP2C9TSHRCYP2C19
SCHEMBL21383437 0.80 CYP1A2 (0.35) CYP1A2CYP3A4CYP2C9TSHRCYP2C19
SCHEMBL21383293 0.80 CYP1A2 (0.35) CYP1A2CYP3A4CYP2C9TSHRCYP2C19
SCHEMBL21383347 0.80 CYP1A2 (0.35) CYP1A2CYP3A4CYP2C9TSHRCYP2C19
SCHEMBL29650847 0.78 GPR52 (0.42) MGAM
SCHEMBL21383018 0.77 CYP1A2 (0.34) CYP1A2CYP3A4CYP2C9TSHRCYP2C19
SCHEMBL21383020 0.77 CYP1A2 (0.34) CYP1A2CYP3A4CYP2C9TSHRCYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0378430-B1 Novel organosilicon compound and process for producing organosilicon compound AGENCY IND SCIENCE TECHN (JP) 1995-02-01 EP disclosed
US-5151538-A ORGANOSILICON COMPOUND AND PROCESS FOR PRODUCING ORGANOSILICON COMPOUND AGENCY OF INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 1992-09-29 US disclosed
EP-0378430-A1 Novel organosilicon compound and process for producing organosilicon compound DIRECTOR-GENERAL OF THE AGENCY OF INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 1990-07-18 EP disclosed