Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 11/20 | 0.64 |
| ▸ | PPARA | Q07869 | 4/20 | 0.48 |
| ▸ | PPARG | P37231 | 8/20 | 0.48 |
| ▸ | ESRRG | P62508 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | DHPS | P49366 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9227079 | 0.98 | NR1H4 (0.62) | NR1H4PPARAPPARGESRRGTP53 | |
| SCHEMBL9221455 | 0.94 | NR1H4 (0.61) | NR1H4PPARAPPARGESRRGPPARD | |
| Hydrochloric Acid SCHEMBL9223842 | 0.93 | NR1H4 (0.60) | NR1H4PPARAPPARGESRRGPPARD | |
| Hydrochloric Acid SCHEMBL9223697 | 0.87 | NR1H4 (0.56) | NR1H4PPARAPPARGPPARDRAB9A | |
| SCHEMBL9221688 | 0.84 | NR1H4 (0.49) | NR1H4PPARAPPARGPPARD | |
| SCHEMBL9229693 | 0.84 | RXFP1 (0.50) | NR1H4PPARAPPARGPPARD | |
| SCHEMBL9228612 | 0.83 | KMT2A (0.55) | NR1H4PPARAPPARGTP53MAPK1 | |
| Hydrochloric Acid SCHEMBL9227330 | 0.82 | NR1H4 (0.47) | NR1H4PPARAPPARGPPARDRAB9A | |
| SCHEMBL9223763 | 0.81 | PPARG (0.60) | NR1H4PPARAPPARGPPARDRAB9A | |
| Hydrochloric Acid SCHEMBL9220369 | 0.81 | NAMPT (0.55) | PPARAPPARGALDH1A1HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5397798-A | Benzamide and sulfonamide hypoglycemic agents | ELI LILLY AND COMPANY (US) | 1995-03-14 | — | — | US | claimed |
| EP-0491525-A1 | Benzamide and sulfonamide hypoglycemic agents | ELI LILLY AND COMPANY (US) | 1992-06-24 | — | — | EP | claimed |
| US-5397798-A | Benzamide and sulfonamide hypoglycemic agents | ELI LILLY AND COMPANY (US) | 1995-03-14 | — | — | US | disclosed |
| EP-0491525-A1 | Benzamide and sulfonamide hypoglycemic agents | ELI LILLY AND COMPANY (US) | 1992-06-24 | — | — | EP | disclosed |