Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 7/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.42 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ACLY | P53396 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3491178 | 0.89 | LMNA (0.52) | PGRLMNASLC12A2SLC12A5POLB | |
| SCHEMBL9219011 | 0.87 | CYP19A1 (0.48) | LMNAACLYALDH1A1 | |
| SCHEMBL3490641 | 0.85 | LMNA (0.52) | LMNAMAPTALDH1A1NSD2 | |
| SCHEMBL3489075 | 0.85 | ALDH1A1 (0.52) | PGRLMNASLC12A2SLC12A5POLB | |
| SCHEMBL9220811 | 0.85 | CYP19A1 (0.45) | POLBACLYALDH1A1CYP3A4CA12 | |
| SCHEMBL9213886 | 0.85 | CYP19A1 (0.51) | PGRPOLBMAPTMEN1KMT2A | |
| SCHEMBL9221821 | 0.84 | CYP19A1 (0.41) | PGRLMNASLC12A2SLC12A5POLB | |
| SCHEMBL9221542 | 0.84 | CYP19A1 (0.43) | PGRPOLBMEN1KMT2AACLY | |
| SCHEMBL3489110 | 0.82 | ALDH1A1 (0.44) | PGRLMNASLC12A2SLC12A5POLB | |
| SCHEMBL3488631 | 0.81 | KMT2A (0.52) | PGRLMNAMEN1KMT2ANR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636124-A1 | 3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-1,1-DIOXIDE-3-CARBOXYLIC ACID DERIVATIVES, PREPARATION THEREOF AND DRUGS CONTAINING SAME | Aventis Pharma S.A. (FR) | 1995-02-01 | — | — | EP | disclosed |
| WO-1993021170-A1 | 3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-1,1-DIOXIDE-3-CARBOXYLIC ACID DERIVATIVES, PREPARATION THEREOF AND DRUGS CONTAINING SAME | RHONE-POULENC RORER S.A. (FR) | 1993-10-28 | — | — | WO | disclosed |