Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.38 |
| ▸ | MAPT | P10636 | 7/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | HCK | P08631 | 4/20 | 0.35 |
| ▸ | SRC | P12931 | 4/20 | 0.35 |
| ▸ | KDR | P35968 | 4/20 | 0.35 |
| ▸ | LCK | P06239 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 7/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9221267 | 0.88 | SMN1; SMN2 (0.40) | RAB9AMAPTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL9218703 | 0.85 | MAPT (0.48) | RAB9AMAPTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL9221055 | 0.85 | RAB9A (0.38) | RAB9AMAPTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL9210159 | 0.85 | RAB9A (0.34) | RAB9AMAPTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL9211898 | 0.83 | RAB9A (0.33) | RAB9AMAPTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL9215126 | 0.83 | SMN1; SMN2 (0.38) | RAB9AMAPTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL9221022 | 0.82 | POLB (0.39) | RAB9AMAPTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL9221803 | 0.82 | ALDH1A1 (0.44) | RAB9AMAPTSMN1; SMN2ALDH1A1HCK | |
| SCHEMBL9164734 | 0.81 | RAB9A (0.35) | RAB9AMAPTSMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL9221145 | 0.81 | CYP17A1 (0.36) | RAB9AMAPTSMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0269859-B2 | Pyrazolotriazine compounds | OTSUKA PHARMA CO LTD (JP) | 1995-10-18 | — | — | EP | disclosed |
| US-4824834-A | TREATING GOUT | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1989-04-25 | — | — | US | disclosed |
| EP-0269859-A2 | Pyrazolotriazine compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-06-08 | — | — | EP | disclosed |