Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | FYN | P06241 | 2/20 | 0.34 |
| ▸ | ACVR2A | P27037 | 2/20 | 0.33 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 6/20 | 0.32 |
| ▸ | RAB9A | P51151 | 5/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9222669 | 0.89 | MAPT (0.38) | MAPTFYNACVR2ATGFBR2ALDH1A1 | |
| SCHEMBL9164734 | 0.81 | RAB9A (0.35) | MAPTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL9172171 | 0.81 | KMT2A (0.40) | MAPTACVR2ATGFBR2ALDH1A1SMN1; SMN2 | |
| SCHEMBL9220988 | 0.81 | MAPT (0.45) | MAPTFYNACVR2ATGFBR2ALDH1A1 | |
| SCHEMBL9218703 | 0.81 | MAPT (0.48) | MAPTFYNACVR2ATGFBR2ALDH1A1 | |
| SCHEMBL9168978 | 0.81 | ALDH1A1 (0.37) | MAPTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL9210159 | 0.79 | RAB9A (0.34) | MAPTFYNALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL9173974 | 0.79 | KDR (0.38) | MAPTFYNTGFBR2SMN1; SMN2NPC1 | |
| SCHEMBL9221267 | 0.79 | SMN1; SMN2 (0.40) | MAPTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL9169069 | 0.79 | KDR (0.33) | MAPTALDH1A1SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0269859-B2 | Pyrazolotriazine compounds | OTSUKA PHARMA CO LTD (JP) | 1995-10-18 | — | — | EP | disclosed |
| US-4824834-A | TREATING GOUT | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1989-04-25 | — | — | US | disclosed |
| EP-0269859-A2 | Pyrazolotriazine compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-06-08 | — | — | EP | disclosed |