Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | FASN | P49327 | 8/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | F12 | P00748 | 1/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.40 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27652147 | 0.84 | PTGDR2 (0.55) | PTGDR2NPC1RAB9ACYP1A2HPGD | |
| SCHEMBL18304696 | 0.83 | PTGDR2 (0.57) | PTGDR2NPC1RAB9A | |
| SCHEMBL5728643 | 0.81 | PTGDR2 (0.51) | PTGDR2NPC1RAB9AGAAKMT2A | |
| SCHEMBL9548868 | 0.80 | ADRB3 (0.39) | PTGDR2FASNKMT2APDK2 | |
| SCHEMBL3911363 | 0.80 | GAA (0.47) | PTGDR2NPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL30280958 | 0.79 | FASN (0.47) | PTGDR2NPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL27832639 | 0.79 | PTGDR2 (0.53) | PTGDR2NPC1RAB9AHPGDGAA | |
| SCHEMBL5517055 | 0.78 | GAA (0.49) | PTGDR2NPC1RAB9AHPGDGAA | |
| SCHEMBL27832665 | 0.77 | PTGDR2 (0.51) | PTGDR2NPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL12488847 | 0.77 | PTGDR2 (0.48) | PTGDR2NPC1RAB9AHPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0635018-A1 | 4-(1H-2-METHYLIMIDAZO 4,5-c]PYRIDINYLMETHYL)PHENYLSULPHONAMIDE DERIVATIVES AS ANTAGONISTS OF PAF | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1995-01-25 | — | — | EP | disclosed |
| EP-0543858-A1 | BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND APPLICATION | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1993-06-02 | — | — | EP | disclosed |