Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.75 |
| ▸ | MASP2 | O00187 | 1/20 | 0.59 |
| ▸ | F2 | P00734 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.54 |
| ▸ | POLB | P06746 | 7/20 | 0.54 |
| ▸ | MAPT | P10636 | 8/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9222011 | 1.00 | HCAR2 (0.75) | HCAR2MASP2F2ALDH1A1POLB | |
| SCHEMBL125126 | 0.87 | HCAR2 (1.00) | HCAR2MASP2F2ALDH1A1POLB | |
| SCHEMBL2561722 | 0.87 | HCAR2 (1.00) | HCAR2MASP2F2ALDH1A1POLB | |
| SCHEMBL125125 | 0.87 | HCAR2 (1.00) | HCAR2MASP2F2ALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL6744115 | 0.85 | HCAR2 (0.96) | HCAR2MASP2F2ALDH1A1POLB | |
| SCHEMBL14088334 | 0.78 | HCAR2 (0.69) | HCAR2MASP2F2ALDH1A1POLB | |
| SCHEMBL3513903 | 0.78 | HCAR2 (0.69) | HCAR2MASP2F2ALDH1A1POLB | |
| SCHEMBL5250151 | 0.78 | HCAR2 (0.69) | HCAR2MASP2F2ALDH1A1POLB | |
| SCHEMBL9112298 | 0.78 | HCAR2 (0.69) | HCAR2MASP2F2ALDH1A1POLB | |
| SCHEMBL10857031 | 0.78 | HCAR2 (0.80) | HCAR2MASP2F2ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0677039-A1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | Abbott Laboratories (US) | 1995-10-18 | — | — | EP | disclosed |