Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 8/20 | 0.69 |
| ▸ | ST14 | Q9Y5Y6 | 3/20 | 0.61 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.53 |
| ▸ | IDO1 | P14902 | 2/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4373482 | 0.98 | MAOB (0.72) | MAOBST14TAAR1IDO1MAPK14 | |
| SCHEMBL108337 | 0.87 | TAAR1 (0.67) | MAOBTAAR1IDO1KMT2A | |
| SCHEMBL920315 | 0.86 | MAOB (0.54) | MAOBST14TAAR1IDO1MAPK14 | |
| Hydrochloric Acid SCHEMBL4019326 | 0.85 | MAOB (0.69) | MAOBTAAR1IDO1KMT2A | |
| Iodide SCHEMBL29187466 | 0.85 | TAAR1 (0.64) | MAOBTAAR1IDO1KMT2A | |
| Bromide SCHEMBL31186283 | 0.85 | TAAR1 (0.64) | MAOBTAAR1IDO1KMT2A | |
| Hydrochloric Acid SCHEMBL923014 | 0.85 | MAOB (0.56) | MAOBST14TAAR1IDO1MAPK14 | |
| SCHEMBL2872345 | 0.85 | TAAR1 (0.78) | MAOBTAAR1IDO1LTA4H | |
| SCHEMBL921317 | 0.84 | MAOB (0.61) | MAOBST14TAAR1IDO1MAPK14 | |
| Hydrochloric Acid SCHEMBL17042516 | 0.83 | TAAR1 (0.75) | MAOBTAAR1IDO1LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994005642-A1 | INDAZOLE DERIVATIVES | CIBA-GEIGY AG (CH) | 1994-03-17 | — | — | WO | claimed |
| US-8153638-B2 | Metabotropic glutamate-receptor-potentiating isoindolones | ASTRAZENECA AB (SE) | 2012-04-10 | — | — | US | disclosed |
| EP-2357169-A1 | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | AstraZeneca AB (SE) | 2011-08-17 | — | — | EP | disclosed |
| WO-2011078370-A1 | NOVEL PARABANIC ACID DERIVATIVE AND DRUG HAVING THE SAME AS ACTIVE INGREDIENT | 杏林製薬株式会社 (JP) | 2011-06-30 | — | — | WO | disclosed |
| US-7968570-B2 | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | ASTRAZENECA AB (SE) | 2011-06-28 | — | — | US | disclosed |
| US-20110009454-A1 | COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2011-01-13 | — | — | US | disclosed |
| US-20100317674-A1 | Metabotropic Glutamate-Receptor-Potentiating Isoindolones | VAN WAGENEN BRADFORD | 2010-12-16 | — | — | US | disclosed |
| EP-2248423-A1 | COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS | Sumitomo Chemical Company, Limited (JP) | 2010-11-10 | — | — | EP | disclosed |
| US-7807706-B2 | Metabotropic glutamate-receptor-potentiating isoindolones | ASTRAZENECA AB (SE) | 2010-10-05 | — | — | US | disclosed |
| US-20090275578-A1 | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | ASTRAZENECA AB (SE) | 2009-11-05 | — | — | US | disclosed |
| US-20080227794-A1 | Metabotropic Glutamate-Receptor-Potentiating Isoindolones | ASTRAZENECA AB (SE) | 2008-09-18 | — | — | US | disclosed |
| EP-1912939-A1 | METABOTROPIC GLUTAMATE-RECEPTOR-POTENTIATING ISOINDOLONES | AstraZeneca AB (SE) | 2008-04-23 | — | — | EP | disclosed |
| EP-1778634-A1 | ISOINDOLONE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | AstraZeneca AB (SE) | 2007-05-02 | — | — | EP | disclosed |
| WO-2007021308-A1 | METABOTROPIC GLUTAMATE-RECEPTOR-POTENTIATING ISOINDOLONES | ASTRAZENECA AB (SE) | 2007-02-22 | — | — | WO | disclosed |
| WO-2006020879-A1 | ISOINDOLONE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | ASTRAZENECA AB (SE) | 2006-02-23 | — | — | WO | disclosed |
| EP-0365925-B1 | Pyrazole amides and insecticide and miticide containing them as active ingredient | MITSUBISHI CHEM CORP (JP) | 1995-07-19 | — | — | EP | disclosed |
| WO-1994005642-A1 | INDAZOLE DERIVATIVES | CIBA-GEIGY AG (CH) | 1994-03-17 | — | — | WO | disclosed |
| US-5039693-A | Pyrazole amides and insecticide and miticide containing them as active ingredient | MITSUBISHI KASEI CORPORATION (JP) | 1991-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317674-A1 | Metabotropic Glutamate-Receptor-Potentiating Isoindolones | GRM1, GRIN1, GRM2 | MAOB 3122/4885ST14 4091/4885TAAR1 219/4885 |
| US-20090275578-A1 | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | GRM1, GRIN1, GRM3 | MAOB 3508/4885ST14 3725/4885TAAR1 286/4885 |
| US-20110009454-A1 | COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS | WIZ, TST, NAT1 | MAOB 3730/4885ST14 708/4885TAAR1 2785/4885 |
| US-20080227794-A1 | Metabotropic Glutamate-Receptor-Potentiating Isoindolones | GRM1, GRIN1, GRM2 | MAOB 3122/4885ST14 4091/4885TAAR1 219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.