Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.72 |
| ▸ | NPC1 | O15118 | 3/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1390576 | 0.85 | RAB9A (0.56) | RAB9ANPC1KMT2AMEN1MAPT | |
| SCHEMBL18982786 | 0.83 | RAB9A (0.57) | RAB9ANPC1KMT2AMEN1MAPT | |
| SCHEMBL30897530 | 0.82 | MAPT (0.53) | RAB9ANPC1KMT2AMEN1MAPT | |
| SCHEMBL9181228 | 0.81 | TAS1R3 (0.58) | RAB9ANPC1KMT2AMEN1MAPT | |
| SCHEMBL27459546 | 0.80 | RAB9A (0.53) | RAB9ANPC1KMT2AMEN1MAPT | |
| SCHEMBL29364254 | 0.79 | MAPT (0.53) | RAB9ANPC1MAPTTP53SMN1; SMN2 | |
| SCHEMBL20952174 | 0.79 | MAPT (0.56) | RAB9ANPC1MAPTTP53SMN1; SMN2 | |
| SCHEMBL17664126 | 0.79 | MAPT (0.60) | RAB9ANPC1MAPTTP53SMN1; SMN2 | |
| SCHEMBL29364250 | 0.79 | MAPT (0.53) | RAB9ANPC1MAPTTP53SMN1; SMN2 | |
| SCHEMBL1101422 | 0.79 | MAPT (0.53) | RAB9ANPC1MAPTTP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0537300-B1 | Oxazolidinedione hypoglycemic and hypocholesterolemic agents | PFIZER (US) | 1995-04-26 | — | — | EP | disclosed |
| EP-0537300-A1 | OXA- AND THIAZOLIDINEDIONE HYPOGLYCEMIC AND HYPOCHOLESTEROLEMIC AGENTS. | PFIZER (US) | 1993-04-21 | — | — | EP | disclosed |
| WO-1991019704-A2 | OXA- AND THIAZOLIDINEDIONE HYPOGLYCEMIC AND HYPOCHOLESTEROLEMIC AGENTS | PFIZER INC. (US) | 1991-12-26 | — | — | WO | disclosed |
| US-5037842-A | Oxa- and thiazolidinedione hypoglycemic and hypocholesterolemic agents | PFIZER INC. (US) | 1991-08-06 | — | — | US | disclosed |