Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26807810 | 0.84 | ALDH1A1 (0.36) | ALDH1A1CYP1A2HSD17B10HPGDCYP2A6 | |
| SCHEMBL26829939 | 0.83 | TSHR (0.46) | ALDH1A1CYP1A2MAPK1HIF1AHSD17B10 | |
| SCHEMBL26829936 | 0.80 | NPC1 (0.37) | ALDH1A1CYP1A2HSD17B10HPGDCYP2A6 | |
| Hydrochloric Acid SCHEMBL8846042 | 0.79 | ALDH1A1 (0.39) | ALDH1A1CYP2D6CYP1A2MAPK1HIF1A | |
| SCHEMBL26808339 | 0.77 | CYP2D6 (0.41) | ALDH1A1CYP2D6CYP1A2MAPK1HIF1A | |
| SCHEMBL16469849 | 0.76 | MAPT (0.39) | ALDH1A1MAPK1HPGDCYP2A6TDP1 | |
| SCHEMBL4076563 | 0.76 | ALDH1A1 (0.50) | ALDH1A1CYP2D6CYP1A2MAPK1HIF1A | |
| SCHEMBL26811153 | 0.75 | CYP3A4 (0.31) | HSD17B10CYP3A4 | |
| SCHEMBL26829940 | 0.73 | ALDH1A1 (0.45) | ALDH1A1CYP2D6CYP1A2MAPK1HIF1A | |
| SCHEMBL26806799 | 0.73 | CA12 (0.35) | ALDH1A1HPGDKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970755-A1 | PREVENTION OF SLUDGE FORMATION DURING ACIDIZING PROCEDURES | Ecolab USA Inc. (US) | 2016-01-20 | — | — | EP | claimed |
| WO-2014149306-A1 | PREVENTION OF SLUDGE FORMATION DURING ACIDIZING PROCEDURES | ECOLAB USA INC. (US) | 2014-09-25 | — | — | WO | claimed |
| US-20140262280-A1 | PREVENTION OF SLUDGE FORMATION DURING ACIDIZING PROCEDURES | ECOLAB USA INC. (US) | 2014-09-18 | — | — | US | claimed |
| EP-0489498-B1 | Acidizing subterranean formations | HALLIBURTON CO (US) | 1994-05-11 | — | — | EP | claimed |
| EP-0489498-A1 | Acidizing subterranean formations | HALLIBURTON COMPANY (US) | 1992-06-10 | — | — | EP | claimed |
| EP-2970755-B1 | PREVENTION OF SLUDGE FORMATION DURING ACIDIZING PROCEDURES | ECOLAB USA INC (US) | 2018-11-14 | — | — | EP | disclosed |
| EP-2970755-A1 | PREVENTION OF SLUDGE FORMATION DURING ACIDIZING PROCEDURES | Ecolab USA Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014149306-A1 | PREVENTION OF SLUDGE FORMATION DURING ACIDIZING PROCEDURES | ECOLAB USA INC. (US) | 2014-09-25 | — | — | WO | disclosed |
| US-20140262280-A1 | PREVENTION OF SLUDGE FORMATION DURING ACIDIZING PROCEDURES | ECOLAB USA INC. (US) | 2014-09-18 | — | — | US | disclosed |
| US-5411670-A | Aqueous liquid carrier and combination of antimony compound activated by a specific condensation product; oil field tubing | HALLIBURTON COMPANY (US) | 1995-05-02 | — | — | US | disclosed |
| US-5366643-A | Method and composition for acidizing subterranean formations | HALLIBURTON COMPANY (US) | 1994-11-22 | — | — | US | disclosed |
| EP-0489498-B1 | Acidizing subterranean formations | HALLIBURTON CO (US) | 1994-05-11 | — | — | EP | disclosed |
| EP-0489498-A1 | Acidizing subterranean formations | HALLIBURTON COMPANY (US) | 1992-06-10 | — | — | EP | disclosed |