Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.42 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.42 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9224447 | 0.89 | NPC1 (0.41) | NPC1RAB9AKCNH2CACNA1FCHRM2 | |
| SCHEMBL10645281 | 0.79 | NPC1 (0.48) | NPC1RAB9AKCNH2CACNA1FCHRM2 | |
| SCHEMBL9226360 | 0.78 | NPC1 (0.42) | NPC1RAB9AKCNH2CACNA1FCHRM2 | |
| SCHEMBL9624560 | 0.77 | KDM4E (0.48) | NPC1RAB9AKCNH2CACNA1FCHRM2 | |
| SCHEMBL9225307 | 0.76 | NR3C1 (0.38) | NPC1RAB9AKCNH2CACNA1FCHRM2 | |
| SCHEMBL9625827 | 0.76 | KDM4E (0.50) | NPC1RAB9AKCNH2CACNA1FCHRM2 | |
| SCHEMBL9624807 | 0.75 | KDM4E (0.49) | NPC1RAB9AKCNH2CACNA1FCHRM2 | |
| SCHEMBL9624842 | 0.75 | PTGS2 (0.48) | NPC1RAB9AKCNH2CACNA1FCHRM2 | |
| SCHEMBL9624979 | 0.75 | ADRB3 (0.61) | NPC1RAB9AKCNH2CACNA1FCHRM2 | |
| SCHEMBL9624818 | 0.75 | ADRB3 (0.61) | NPC1RAB9AKCNH2CACNA1FCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0484378-B1 | ANTIARRHYTHMIC TERTIARY AMINE-ALKENYL-PHENYL-ALKANESULFONAMIDES | UPJOHN CO (US) | 1994-09-14 | — | — | EP | claimed |
| EP-0484378-A1 | ANTIARRHYTHMIC TERTIARY AMINE-ALKENYL-PHENYL-ALKANESULFONAMIDES. | UPJOHN CO (US) | 1992-05-13 | — | — | EP | claimed |
| WO-1991001299-A1 | ANTIARRHYTHMIC TERTIARY AMINE-ALKENYL-PHENYL-ALKANESULFONAMIDES | THE UPJOHN COMPANY (US) | 1991-02-07 | — | — | WO | claimed |
| US-5405997-A | Stable against rapid metabolism | THE UPJOHN COMPANY (US) | 1995-04-11 | — | — | US | disclosed |
| EP-0484378-B1 | ANTIARRHYTHMIC TERTIARY AMINE-ALKENYL-PHENYL-ALKANESULFONAMIDES | UPJOHN CO (US) | 1994-09-14 | — | — | EP | disclosed |