Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 3/20 | 0.37 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3130902 | 0.91 | EPHX2 (0.48) | ALDH1A1PARP10EPHX2LMNACASP3 | |
| SCHEMBL8499078 | 0.89 | ALDH1A1 (0.46) | ALDH1A1PARP10EPHX2LMNABTK | |
| SCHEMBL9259518 | 0.82 | EPHX2 (0.41) | ALDH1A1PARP10EPHX2LMNACASP3 | |
| SCHEMBL11755572 | 0.75 | PARP10 (0.71) | ALDH1A1PARP10EPHX2LMNACASP3 | |
| SCHEMBL9082265 | 0.75 | ALDH1A1 (0.35) | ALDH1A1PARP10BTK | |
| SCHEMBL14339546 | 0.74 | MAPT (0.49) | ALDH1A1PARP10LMNABTK | |
| SCHEMBL15131945 | 0.73 | PARP10 (0.58) | ALDH1A1PARP10EPHX2LMNACASP3 | |
| SCHEMBL6254824 | 0.73 | SRC (0.41) | ALDH1A1LMNATDP1 | |
| SCHEMBL1028676 | 0.72 | EPHX2 (0.68) | ALDH1A1PARP10EPHX2LMNACASP3 | |
| SCHEMBL4371441 | 0.72 | HRH1 (0.44) | ALDH1A1PARP10BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0677039-A1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | Abbott Laboratories (US) | 1995-10-18 | — | — | EP | disclosed |