SCHEMBL9225218

SCHEMBL9225218

CCCCOC1(OC(F)(F)F)C=CC(c2ccccc2F)=CC1

nearest known ligand 0.32

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PDK2 Q15119 3/20 0.32
CYP2C9 P11712 1/20 0.31
CYP2C19 P33261 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9227211 0.97 PDK2 (0.33) PDK2CYP2C9CYP2C19NPSR1
SCHEMBL9228706 0.96 PDK2 (0.34) PDK2CYP2C9CYP2C19NPSR1
SCHEMBL9225241 0.96 PDK2 (0.34) PDK2CYP2C9CYP2C19NPSR1
SCHEMBL9219071 0.96 PDK2 (0.34) PDK2CYP2C9CYP2C19NPSR1
SCHEMBL9223753 0.96 PDK2 (0.34) PDK2CYP2C9CYP2C19NPSR1
SCHEMBL9223531 0.96 PDK2 (0.34) PDK2CYP2C9CYP2C19NPSR1
SCHEMBL9223485 0.93
SCHEMBL9221755 0.89 KDM4E (0.30)
SCHEMBL28005983 0.86 L3MBTL1 (0.36) PDK2CYP2C9CYP2C19NPSR1
SCHEMBL9226129 0.80

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0413785-B1 LIQUID CRYSTALLINE MEDIA CONTAINING FLUORINATED OLIGOPHENYLS MERCK PATENT GMBH (DE) 1995-12-20 EP disclosed
EP-0413785-A1 LIQUID CRYSTALLINE MEDIA CONTAINING FLUORINATED OLIGOPHENYLS. MERCK PATENT GMBH (DE) 1991-02-27 EP disclosed
WO-1990009420-A1 LIQUID CRYSTALLINE MEDIA CONTAINING FLUORINATED OLIGOPHENYLS MERCK Patent Gesellschaft mit beschränkter Haftung (DE) 1990-08-23 WO disclosed