Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28725576 | 0.79 | SMN1; SMN2 (0.47) | SMN1; SMN2HTTL3MBTL1CYP2D6POLB | |
| SCHEMBL8712186 | 0.74 | SMN1; SMN2 (0.42) | SMN1; SMN2HTTL3MBTL1CYP2D6POLB | |
| SCHEMBL23175194 | 0.72 | SMN1; SMN2 (0.46) | SMN1; SMN2HTTL3MBTL1CYP2D6POLB | |
| SCHEMBL3749371 | 0.72 | SMN1; SMN2 (0.46) | SMN1; SMN2HTTL3MBTL1CYP2D6POLB | |
| SCHEMBL18379267 | 0.71 | SMN1; SMN2 (0.49) | SMN1; SMN2HTTL3MBTL1CYP2D6POLB | |
| SCHEMBL14565210 | 0.71 | SMN1; SMN2 (0.49) | SMN1; SMN2HTTL3MBTL1CYP2D6POLB | |
| SCHEMBL27567594 | 0.67 | CHRM2 (0.48) | SMN1; SMN2HTTL3MBTL1CYP2D6 | |
| SCHEMBL8712184 | 0.63 | METAP1 (0.33) | SMN1; SMN2S1PR1S1PR3S1PR5CYP2D6 | |
| SCHEMBL689750 | 0.62 | SMN1; SMN2 (0.63) | SMN1; SMN2HTTL3MBTL1CYP2D6POLB | |
| SCHEMBL6206557 | 0.62 | SMN1; SMN2 (0.63) | SMN1; SMN2HTTL3MBTL1CYP2D6POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0642518-A1 | PHOSPHONOSULFONATE COMPOUNDS FOR TREATING ABNORMAL CALCIUM AND PHOSPHATE METABOLISM | PROCTER & GAMBLE PHARMACEUTICALS (US) | 1995-03-15 | — | — | EP | disclosed |
| WO-1993024495-A1 | PHOSPHONOSULFONATE COMPOUNDS FOR TREATING ABNORMAL CALCIUM AND PHOSPHATE METABOLISM | PROCTER & GAMBLE PHARMACEUTICALS, INC. (US) | 1993-12-09 | — | — | WO | disclosed |