SCHEMBL8712184

SCHEMBL8712184

CN1CCCC(CC(P(=O)(O)O)S(=O)(=O)O)C1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
METAP1 P53582 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
GFER P55789 1/20 0.32
CHRNB2 P17787 1/20 0.31
CHRNB4 P30926 1/20 0.31
CHRNA3 P32297 1/20 0.31
CHRNA4 P43681 1/20 0.31
CHRM2 P08172 2/20 0.30
ADRA2A P08913 2/20 0.30
CHRM1 P11229 2/20 0.30
DRD1 P21728 2/20 0.30
SLC6A2 P23975 2/20 0.30
SLC6A4 P31645 2/20 0.30
ADRA1A P35348 2/20 0.30
OPRM1 P35372 2/20 0.30
DRD3 P35462 2/20 0.30
KCNH2 Q12809 2/20 0.30
HRH3 Q9Y5N1 2/20 0.30
ABCB11 O95342 1/20 0.30
CHRM4 P08173 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8712088 0.75 CYP1A2 (0.39) ADRA2AS1PR4S1PR1S1PR3S1PR5
Iodide SCHEMBL8712885 0.72 CHRNB2 (0.30) CHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL8711864 0.72 CPN1 (0.46) METAP1SMN1; SMN2LMNACYP2D6TSHR
SCHEMBL23160555 0.71 INPP5A (0.40) SMN1; SMN2GFERCHRNB2CHRNB4CHRNA3
SCHEMBL23160556 0.71 INPP5A (0.40) SMN1; SMN2GFERCHRNB2CHRNB4CHRNA3
SCHEMBL8711893 0.70 ATM (0.32) SMN1; SMN2GFERCHRNB2CHRNB4CHRNA3
SCHEMBL8712189 0.70 CACNA2D1 (0.33) SMN1; SMN2S1PR1S1PR3S1PR5
SCHEMBL29252680 0.69 SMN1; SMN2 (0.38) SMN1; SMN2GFERCHRNB2CHRNB4CHRNA3
SCHEMBL25660551 0.69 GFER (0.39) SMN1; SMN2GFERCHRNB2CHRNB4CHRNA3
SCHEMBL9925436 0.68 CHRM2 (0.38) SMN1; SMN2GFERCHRNB2CHRNB4CHRNA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1255501-A Novel phosphonyl sulfonic ester compound and its medicinal compsns. PROCTER & GAMBLE PHARMA (US) 2000-06-07 CN disclosed
CN-1229083-A Novel phosphononosulfonate compounds and its pharmaceutical compositions PROCTER & GAMBLE PHARMA (US) 1999-09-22 CN disclosed
EP-0642518-B1 PHOSPHONOSULFONATE COMPOUNDS FOR TREATING ABNORMAL CALCIUM AND PHOSPHATE METABOLISM PROCTER & GAMBLE PHARMA (US) 1998-08-05 EP disclosed
US-5731299-A OSTEOPOROSIS; RHEUMATOID ARTHRITIS THE PROCTER & GAMBLE COMPANY (US) 1998-03-24 US disclosed
EP-0642518-A1 PHOSPHONOSULFONATE COMPOUNDS FOR TREATING ABNORMAL CALCIUM AND PHOSPHATE METABOLISM PROCTER & GAMBLE PHARMACEUTICALS (US) 1995-03-15 EP disclosed
CN-1087640-A Novel phosphonosulfonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism PROCTER & GAMBLE PHARMA (US) 1994-06-08 CN disclosed
WO-1993024495-A1 PHOSPHONOSULFONATE COMPOUNDS FOR TREATING ABNORMAL CALCIUM AND PHOSPHATE METABOLISM PROCTER & GAMBLE PHARMACEUTICALS, INC. (US) 1993-12-09 WO disclosed