Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.47 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.47 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9625149 | 0.89 | CACNA1F (0.50) | KCNH2CACNA1FCHRM2ADRA2BADRA2C | |
| SCHEMBL9228476 | 0.82 | CACNA1F (0.46) | KCNH2CACNA1FCHRM2ADRA2BADRA2C | |
| SCHEMBL9625631 | 0.74 | KDM4E (0.58) | KCNH2CACNA1FCHRM2ADRA2BADRA2C | |
| SCHEMBL9218456 | 0.73 | KCNH2 (0.83) | KCNH2CACNA1FCHRM2ADRA2BADRA2C | |
| SCHEMBL9224529 | 0.73 | CACNA1F (0.43) | KCNH2CACNA1FCHRM2ADRA2BADRA2C | |
| SCHEMBL13545194 | 0.70 | KDM4E (0.59) | KDM4ELMNAHPGDALDH1A1HTT | |
| SCHEMBL9225020 | 0.69 | KCNH2 (0.56) | KCNH2CACNA1FCHRM2ADRA2BADRA2C | |
| SCHEMBL8899350 | 0.69 | KCNH2 (0.46) | KCNH2CACNA1FCHRM2ADRA2BADRA2C | |
| SCHEMBL9225025 | 0.69 | KCNH2 (0.56) | KCNH2CACNA1FCHRM2ADRA2BADRA2C | |
| SCHEMBL6560601 | 0.69 | HPGD (0.58) | KDM4ELMNAHPGDALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5405997-A | Stable against rapid metabolism | THE UPJOHN COMPANY (US) | 1995-04-11 | — | — | US | disclosed |
| EP-0484378-B1 | ANTIARRHYTHMIC TERTIARY AMINE-ALKENYL-PHENYL-ALKANESULFONAMIDES | UPJOHN CO (US) | 1994-09-14 | — | — | EP | disclosed |
| EP-0484378-A1 | ANTIARRHYTHMIC TERTIARY AMINE-ALKENYL-PHENYL-ALKANESULFONAMIDES. | UPJOHN CO (US) | 1992-05-13 | — | — | EP | disclosed |
| WO-1991001299-A1 | ANTIARRHYTHMIC TERTIARY AMINE-ALKENYL-PHENYL-ALKANESULFONAMIDES | THE UPJOHN COMPANY (US) | 1991-02-07 | — | — | WO | disclosed |