Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.51 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 5/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9624600 | 0.85 | KDM4E (0.63) | KDM4ECACNA1FCHRM2DRD3CACNA1D | |
| SCHEMBL9625141 | 0.85 | THRA (0.52) | KDM4ECACNA1FCHRM2ADRA2BADRA2C | |
| SCHEMBL9625149 | 0.85 | CACNA1F (0.50) | KDM4ECACNA1FCHRM2ADRA2BADRA2C | |
| SCHEMBL9625821 | 0.81 | KCNH2 (0.66) | KDM4ECACNA1FCHRM2ADRA2BADRA2C | |
| SCHEMBL9624804 | 0.81 | KCNH2 (0.66) | KDM4ECACNA1FCHRM2ADRA2BADRA2C | |
| SCHEMBL16976564 | 0.80 | KDM4E (0.65) | KDM4ECACNA1FCHRM2ADRA2BADRA2C | |
| Hydrochloric Acid SCHEMBL10529761 | 0.80 | KCNH2 (0.65) | KDM4ECACNA1FCHRM2ADRA2BADRA2C | |
| Bromide SCHEMBL10529006 | 0.80 | KCNH2 (0.65) | KDM4ECACNA1FCHRM2ADRA2BADRA2C | |
| SCHEMBL10528894 | 0.80 | KCNH2 (0.57) | KDM4ECACNA1FCHRM2ADRA2BADRA2C | |
| SCHEMBL7998829 | 0.79 | GRIN1 (0.63) | KDM4EKCNH2GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155268-A | Antiarrhythmic N-aminoalkylene alkyl and aryl sulfonamides | THE UPJOHN COMPANY (US) | 1992-10-13 | — | — | US | disclosed |
| EP-0164865-B1 | N-(AMINOALKYLPHENYL)SULFONAMIDES THEIR PREPARATION AND THERAPEUTIC USE | THE UPJOHN COMPANY (US) | 1988-12-21 | — | — | EP | disclosed |
| EP-0164865-A1 | N-(Aminoalkylphenyl)sulfonamides their preparation and therapeutic use | THE UPJOHN COMPANY (US) | 1985-12-18 | — | — | EP | disclosed |