Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 3/20 | 0.46 |
| ▸ | HTR2C known ✓ | P28335 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9229251 | 1.00 | HTR2A (0.46) | HTR2AKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8711222 | 0.95 | HTR2A (0.48) | HTR2AKDM4ECYP1A2CYP3A4CYP2D6 | |
| Fumaric Acid SCHEMBL8712103 | 0.88 | SMN1; SMN2 (0.47) | HTR2AKDM4ECYP1A2CYP3A4CYP2D6 | |
| Fumaric Acid SCHEMBL8712106 | 0.88 | SMN1; SMN2 (0.47) | HTR2AKDM4ECYP1A2CYP3A4CYP2D6 | |
| Fumaric Acid SCHEMBL9230577 | 0.87 | CYP2D6 (0.48) | HTR2AKDM4ECYP1A2CYP3A4CYP2D6 | |
| Fumaric Acid SCHEMBL9230570 | 0.87 | CYP2D6 (0.48) | HTR2AKDM4ECYP1A2CYP3A4CYP2D6 | |
| Fumaric Acid SCHEMBL9233366 | 0.84 | HSD11B1 (0.48) | HTR2AKDM4ECYP1A2CYP3A4CYP2D6 | |
| Fumaric Acid SCHEMBL9233361 | 0.84 | HSD11B1 (0.48) | HTR2AKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8711392 | 0.83 | HTR2A (0.53) | HTR2AKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8713815 | 0.83 | MEN1 (0.49) | HTR2AKDM4ECYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661266-A1 | Substituted cyclic amine compounds as 5HT2 antagonists | TOA EIYO LTD. (JP) | 1995-07-05 | — | — | EP | disclosed |